Evidence map›Paper›PMID 39711538›Full record

ArticleResearch square2024

Personalized bone organoid using iPSC-derived cells for clinically relevant applications.

Qi Gao, Victoria Teissier, Wenjuan Zhu, Meagan J Makarcyzk, Issei Shinohara, Masatoshi Murayama, Yosuke Susuki, Simon Kwoon-Ho Chow, Bruce A Bunnell, Joy Wu and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qi GaoOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Victoria TeissierOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Wenjuan ZhuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Meagan J MakarcyzkCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Issei ShinoharaOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Masatoshi MurayamaOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Yosuke SusukiOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Simon Kwoon-Ho ChowOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Bruce A BunnellDepartment of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Joy WuDivision of Endocrinology, Stanford University School of Medicine, Stanford, CA 94304, USA.
Hang LinCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.ORCID 0000-0002-0781-6630
Stuart B GoodmanOrthopaedic Research Laboratories, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.

Funding

Tissue Chip Modeling of Synovial Joint Pathologies: Effects of Inflammation and Adipose-Mediated Diabetic ComplicationsUG3TR002136 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUAN, ROCKY S · 2017 to 2018
$2.5M
Neurophysiology of Weakness and Exercise in Rotator Cuff TendinopathyR01AR063713 · NIAMS · UNIVERSITY OF OREGON · PI KARDUNA, ANDREW ROBERT · 2014 to 2018
$1.7M
Customized MSCs to Enhance Healing of Bone DefectsR01AR073145 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2018 to 2021
$1.4M
NCATS NIH HHS UG3 TR002136NIAMS NIH HHS R01 AR063713NIAMS NIH HHS R01 AR073145
6 · The paper itself

Abstract

Patient-specific induced pluripotent stem cells (iPSCs)-based modeling potentially recapitulates the pathology and mechanisms more faithfully than cell line models and general animal models. Utilizing iPSC-derived cells for personalized bone formation research offers a powerful tool to better understand the role of individual differences in bone health and disease and provide more precise information for personalized bone regeneration therapies. Here we generated iPSC-derived mesenchymal progenitor cells (iMPCs), endothelial cells (iECs), and macrophages (iMØ), from different donors. Cellular markers, pluripotency properties, and immune regulatory properties were investigated. To replicate bone regeneration, we utilize different iPSC models and co-cultured three distinct cell types (iMPCs, iECs, and iMØ) in a 3D in vitro model derived from the same donor. Cells from different donors exhibited patient-specific characteristics and different regenerative capacities. Our study suggests that cells differentiated from iPSCs can be used to anticipate the effectiveness of cell-based therapies for personalized tissue regeneration.

Indexed as

bone modelingheterogeneitypersonalized medicineStem cell

Identifiers

PMID39711538
PMCPMC11661298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.