Evidence map›Paper›PMID 39711711›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Dominant negative

Marjon Wouters, Lisa Ehlers, Wout Van Eynde, Meltem Ece Kars, Selket Delafontaine, Verena Kienapfel, Mariia Dzhus, Rik Schrijvers, Petra De Haes, Sofie Struyf and 8 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Marjon WoutersLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0002-4675-1665
Lisa EhlersLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8737-001X
Wout Van EyndeBiochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, Leuven, Belgium.ORCID 0000-0001-9426-862X
Meltem Ece KarsThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai. New York City, United States of America.ORCID 0000-0001-5922-5608
Selket DelafontaineLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0002-8985-8155
Verena KienapfelLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Mariia DzhusLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0002-2077-4295
Rik SchrijversAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0002-4261-6220
Petra De HaesDepartment of Dermatology, UZ Leuven, Leuven, Belgium.ORCID 0000-0001-6503-6088
Sofie StruyfMolecular Immunology (Rega Institute), Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.ORCID 0000-0003-4558-0769
Giorgia BucciolLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0001-5004-0738
Yuval ItanBiochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, Leuven, Belgium.ORCID 0000-0003-4966-3238
Alexandre BolzeHelix, San Mateo, CA, United States of America.ORCID 0000-0001-7399-2766
Arnout VoetBiochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3329-2703
Anneleen HombrouckLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Leen MoensLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0002-5347-6526
Benson OgunjimiDepartment of Pediatrics, Antwerp University Hospital, Antwerp, Belgium.ORCID 0000-0002-0831-2063
Isabelle MeytsLaboratory Inborn errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1214-0302

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
NCATS NIH HHS UL1 TR004419
6 · The paper itself

Abstract

Human ADA2 deficiency (DADA2) is an inborn error of immunity with a broad clinical phenotype which encompasses vasculopathy including livedo racemosa and lacunar strokes, as well as hemato-immunological features. Diagnosis is based on the combination of decreased serum ADA2 activity and the identification of biallelic deleterious alleles in the

Identifiers

PMID39711711
PMCPMC11661335

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.