ArticlemedRxiv : the preprint server for health sciences2023
Muscle mitochondrial bioenergetic capacities is associated with multimorbidity burden in older adults: the Study of Muscle, Mobility and Aging (SOMMA).
Theresa Mau, Terri L Blackwell, Peggy M Cawthon, Anthony J A Molina, Paul M Coen, Giovanna Distefano, Philip A Kramer, Sofhia V Ramos, Daniel E Forman, Bret H Goodpaster and 6 more
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors.
Theresa MauSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California.ORCID 0000-0003-4278-6438 Terri L BlackwellSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California.ORCID 0000-0003-0012-7020 Peggy M CawthonSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California.ORCID 0000-0003-4938-9478 Anthony J A MolinaDepartment of Medicine-Division of Geriatrics, Gerontology, and Palliative Care, University of California San Diego School of Medicine, La Jolla, California.
Philip A KramerDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0001-6554-631X Daniel E FormanDepartment of Medicine-Division of Geriatrics and Cardiology, University of Pittsburgh, Geriatrics Research, Education, and Clinical Care (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.
Bret H GoodpasterTranslational Research Institute, AdventHealth, Orlando, Florida.
Frederico G S ToledoDepartment of Medicine-Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-6570-9948 Kate A DuchownySocial Environment and Health, Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0001-9771-8454 Lauren M SparksTranslational Research Institute, AdventHealth, Orlando, Florida.
Stephen B KritchevskyDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0003-3336-6781 Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California.
Funding
Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · 2025 to 2025
$15.0MWake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2002 to 2025
$7.7MTECHNOLOGY COREP30AG024827 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2004 to 2025
$4.3MExamining the role of the neighborhood environment on muscle function in older adultsR00AG066846 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$244kNCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R00 AG066846NIA NIH HHS R01 AG059416
6 · The paper itselfAbstract
Background: The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity. Methods: The Study of Muscle, Mobility and Aging (SOMMA) assessed Results: Lower oxidative phosphorylation supported by fatty acids and/or complex-I and -II linked carbohydrates (e.g., Max OXPHOS Conclusions: Lower muscle mitochondrial bioenergetic capacities was associated with a worse composite multimorbidity index score. Our results suggest that decrements in muscle mitochondrial energetics may contribute to a greater global burden of disease and is more strongly related to some conditions than others.
Indexed as
aging musclebioenergeticsmitochondriamultimorbidity
Identifiers
PMID39711735
PMCPMC11661392
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