Evidence map›Paper›PMID 39713377›Full record

ArticlebioRxiv : the preprint server for biology2025

Differing genetics of saline and cocaine self-administration in the hybrid mouse diversity panel.

Arshad H Khan, Jared R Bagley, Nathan LaPierre, Carlos Gonzalez-Figueroa, Tadeo C Spencer, Mudra Choudhury, Xinshu Xiao, Eleazar Eskin, James D Jentsch, Desmond J Smith

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Arshad H KhanDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095.ORCID 0000-0001-8725-3948
Jared R BagleyDepartment of Psychology, Binghamton University, Binghamton, NY 13902.ORCID 0000-0002-9972-6498
Nathan LaPierreDepartment of Computer Science, UCLA, Los Angeles, CA 90095.ORCID 0000-0003-2394-8868
Carlos Gonzalez-FigueroaDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA 90095.ORCID 0000-0001-5846-1393
Tadeo C SpencerDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA 90095.ORCID 0000-0002-2525-175X
Mudra ChoudhuryDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA 90095.ORCID 0000-0002-7557-4661
Xinshu XiaoDepartment of Integrative Biology and Physiology, UCLA, Los Angeles, CA 90095.ORCID 0000-0002-9362-8029
Eleazar EskinDepartment of Computational Medicine, UCLA, Los Angeles, CA 90095.ORCID 0000-0003-1149-4758
James D JentschDepartment of Psychology, Binghamton University, Binghamton, NY 13902.ORCID 0000-0002-6483-8844
Desmond J SmithDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095.ORCID 0000-0003-1215-3656

Funding

Project 5: Circadian RhythmsP50DA039841 · NIDA · JACKSON LABORATORY · PI J. DAVID JENTSCH · 2016 to 2026
$26.2M
Genetic pathways for impulsivity and drug reinforcement: DNA and transcriptome variation in miceU01DA041602 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR, JENTSCH, J. DAVID · 2017 to 2021
$3.2M
Systematic approaches to deciphering regulation and function of RNA editing in brainR01MH123177 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI XIAO, XINSHU GRACE · 2021 to 2025
$3.1M
Development and Neuroadaptations in Alcohol and Addictions (DNA2)T32AA025606 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI J. DAVID JENTSCH · 2017 to 2026
$2.7M
NIAAA NIH HHS T32 AA025606NIDA NIH HHS P50 DA039841NIDA NIH HHS U01 DA041602NIMH NIH HHS R01 MH123177
6 · The paper itself

Abstract

To identify genes that regulate the response to the potentially addictive drug cocaine, we performed a control experiment using genome-wide association studies (GWASs) and RNA-Seq of a panel of inbred and recombinant inbred mice undergoing intravenous self-administration of saline. A linear mixed model increased statistical power for analysis of the longitudinal behavioral data, which was acquired over 10 days. A total of 145 loci were identified for saline compared to 17 for the corresponding cocaine GWAS. Only one locus overlapped. Transcriptome-wide association studies (TWASs) using RNA-Seq data from the nucleus accumbens and medial frontal cortex identified

Identifiers

PMID39713377
PMCPMC11661131

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.