Evidence map›Paper›PMID 39713413›Full record

ArticlebioRxiv : the preprint server for biology2025

Caveolin-1 regulates context-dependent signaling and survival in Ewing sarcoma.

Dagan Segal, Xiaoyu Wang, Hanieh Mazloom-Farisbaf, Divya Rajendran, Erin Butler, Bingying Chen, Bo-Jui Chang, Khushi Ahuja, Averi Perny, Kushal Bhatt and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Dagan SegalLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0003-0852-6501
Xiaoyu WangDepartment of Biochemistry, UT Southwestern Medical Center, Dallas, TX.
Hanieh Mazloom-FarisbafLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Divya RajendranLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Erin ButlerDepartment of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bingying ChenLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Bo-Jui ChangLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Khushi AhujaLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Averi PernyLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Kushal BhattLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Dana Kim ReedLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Diego H CastrillonDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX.
Jeon LeeLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Elise JefferyChildren's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX.
Lei WangLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Khai NguyenDepartment of Biophysics, UT Southwestern Medical Center, Dallas, TX.
Noelle S WilliamsDepartment of Biochemistry, UT Southwestern Medical Center, Dallas, TX.
Stephen X SkapekDepartment of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Satwik RajaramLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Reto FiolkaLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Khuloud JaqamanLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.
Gary HonLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0002-1615-0391
James F AmatrudaDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA.ORCID 0000-0002-9901-2137
Gaudenz DanuserLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-8583-2014

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Targeting EWSR1-FLI1 through Functional, Structural and Chemical ApproachesU54CA231649 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI AMATRUDA, JAMES F, MCFADDEN, DAVID GLENN · 2019 to 2019
$10.0M
Technical Development Unit 2: Intelligent Hyperspectral Imaging of Subcellular Molecular States at the Whole Organ LevelU54CA268072 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI JAMES F AMATRUDA · 2021 to 2026
$9.1M
Mechanisms and Functional Consequences of Signaling Protein Organization at MembranesR35GM119619 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DASGUPTA, APARAJITA KAMALESH · 2016 to 2025
$4.3M
Functional causality in regulating cell morphogenesisR35GM136428 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DANUSER, GAUDENZ · 2020 to 2024
$4.1M
Multiscale microscope for 3D cancer imaging in model organisms and organoidsR33CA235254 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FIOLKA, RETO PAUL · 2019 to 2021
$930k
Spinning Disk Confocal for UT SouthwesternS10OD028630 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2020 to 2020
$600k
The context-dependent role of Caveolin-1 as a driver of cellular adaptation in Ewing SarcomaK99CA270285 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SEGAL, DAGAN · 2023 to 2024
$302k
Data-driven mechanistic models of morphology-controlled Ras oncogenic signalingK99CA283246 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Hanieh Mazloom Farsibaf · 2025 to 2026
$280k
High-performance slide scanner for multichannel fluorescence, brightfield and polarizationS10OD032267 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI RAMIREZ, DENISE MARIE · 2022 to 2022
$208k
NCI NIH HHS K99 CA270285NCI NIH HHS K99 CA283246NCI NIH HHS P30 CA142543NCI NIH HHS R33 CA235254NCI NIH HHS U54 CA231649NCI NIH HHS U54 CA268072NIGMS NIH HHS R35 GM119619NIGMS NIH HHS R35 GM136428NIH HHS S10 OD028630NIH HHS S10 OD032267
6 · The paper itself

Abstract

Plasticity is a hallmark function of cancer cells, but many of the underlying mechanisms have yet to be discovered. In this study, we identify Caveolin-1, a scaffolding protein that organizes plasma membrane domains, as a context-dependent regulator of survival signaling in Ewing sarcoma (EwS). Single cell analyses reveal a distinct subpopulation of EwS cells, which highly express the surface marker CD99 as well as Caveolin-1.

Identifiers

PMID39713413
PMCPMC11661136

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.