Evidence map›Paper›PMID 39714119›Full record

ArticleMovement disorders clinical practice2025

Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus.

Aino M Kuusela, Emma A Honkanen, Elina Jaakkola, Elina Myller, Mikael Eklund, Simo Nuuttila, Kirsi-Marja Murtomäki, Tuomas Mertsalmi, Reeta Levo, Toni Ihalainen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aino M KuuselaClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0009-0004-1203-7828
Emma A HonkanenClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0003-3497-5706
Elina JaakkolaClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-8003-1346
Elina MyllerClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0001-7591-1990
Mikael EklundClinical Neurosciences, University of Turku, Turku, Finland.
Simo NuuttilaClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-1749-7936
Kirsi-Marja MurtomäkiDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-5759-1911
Tuomas MertsalmiDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Helsinki, Finland.
Reeta LevoDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Helsinki, Finland.
Toni IhalainenDepartment of Clinical Physiology and Nuclear Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Tommi NoponenDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Tero VahlbergDepartment of Biostatistics, Faculty of Medicine, University of Turku, Turku, Finland.
Juho JoutsaClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-3457-9415
Filip ScheperjansDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-9502-7131
Valtteri KaasinenClinical Neurosciences, University of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-3446-7093

Funding

The Finnish Cultural FoundationThe Finnish Foundation for Alcohol StudiesThe Finnish Parkinson FoundationThe Päivikki and Sakari Sohlberg FoundationTurku University Hospital (VTR-funds)
6 · The paper itself

Abstract

backgroundWhile previous imaging studies have generally shown normal striatal dopamine transporter (DAT) binding in essential tremor (ET), emerging evidence suggests a partial dopaminergic mechanism in this condition and an epidemiological link between ET and Parkinson's disease (PD). This link seems particularly meaningful in ET patients with additional neurological signs, such as slowness of movements, rigidity, or rest tremor (ET+).

objectivesTo investigate the potential dopaminergic pathophysiology of ET+ and to compare it to PD.

methodsFourty-three ET+ patients, 115 PD patients and 40 healthy controls were studied using [

resultsBradykinesia scores were negatively associated with posterior putamen DAT binding in both the ET+ and PD groups, with the strongest correlation observed in finger tapping (F = 11.1, β = -0.10, 95%CI -0.16 to -0.04, P = 0.001). In ET+ patients, kinetic tremor asymmetry correlated with posterior putamen DAT binding asymmetry (r = 0.33, P = 0.043), indicating a relationship between more severe tremor and subtle contralateral DAT loss.

conclusionsIn ET+, subtle increases in bradykinesia scores correlate with striatal dopaminergic dysfunction, while kinetic tremor asymmetry is associated with hemispheric DAT binding asymmetry. These findings support the concept of partial dopaminergic involvement in the pathophysiology of ET+.

Indexed as

Corpus StriatumDopamineDopamine Plasma Membrane Transport ProteinsEssential TremorAgedAged, 80 and overFemaleHumansMaleMiddle AgedParkinson DiseaseTomography, Emission-Computed, Single-PhotonTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneDopamineDopamine Plasma Membrane Transport ProteinsTropanesessential tremorParkinson's diseasetremor

Identifiers

PMID39714119
PMCPMC11998700

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.