Evidence map›Paper›PMID 39714320›Full record

ArticleEmerging infectious diseases2025

Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in KPC-Producing Klebsiella pneumoniae.

Riccardo Polani, Alice De Francesco, Dario Tomolillo, Irene Artuso, Michele Equestre, Rita Trirocco, Gabriele Arcari, Guido Antonelli, Laura Villa, Gianni Prosseda and 2 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Influence of iron uptake systems on cefiderocol activity inAntimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Article
  4. KPC-producing Klebsiella pneumoniae in Switzerland from 2024 to 2025: comparative genomics and cefiderocol resistance mechanisms analyses.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Genetic characterization of carbapenem-resistantFrontiers in cellular and infection microbiology · 2026
    Article
  11. Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2026
    Review
  12. Siderophore cephalosporins.EcoSal Plus · 2025
    Review
  13. Review
  14. Article
  15. Spontaneous Emergence of Cefiderocol Resistance inAntibiotics (Basel, Switzerland) · 2025
    Article
  16. Review
  17. Review
  18. Outbreak of High-Risk Clone ST323Antibiotics (Basel, Switzerland) · 2025
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Riccardo Polani
Alice De Francesco
Dario Tomolillo
Irene Artuso
Michele Equestre
Rita Trirocco
Gabriele Arcari
Guido Antonelli
Laura Villa
Gianni Prosseda
Paolo Visca
Alessandra Carattoli

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cefiderocol (FDC), a siderophore-cephalosporin conjugate, is the newest option for treating infection with carbapenem-resistant gram-negative bacteria. We identified a novel mechanism contributing to decreased FDC susceptibility in Klebsiella pneumoniae clinical isolates. The mechanism involves 2 coresident plasmids: pKpQIL, carrying variants of bla

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCefiderocolFerric CompoundsKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPlasmidsCephalosporinsDrug Resistance, BacterialEscherichia coliHumansWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCefiderocolCephalosporinsferric citrateFerric Compoundsantimicrobial resistancebacteriacarbapenemase-producing Klebsiella pneumoniaecefiderocolferric citrate-dependent iron transport systemItalyKlebsiella pneumoniaeKPCsiderophore

Identifiers

PMID39714320
PMCPMC11682805

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.