Evidence map›Paper›PMID 39714583›Full record

ArticleOdontology2025

Polymorphisms in nanog are associated with oral leukoplakia: case-control study.

Arieli Carini Michels, Suelen Teixeira Scheifer, Fernanda Tiboni, Filipe Modolo, Emanuela Carla Dos Santos, Rafaela Scariot, Maria Cassia Ferreira Aguiar, Sergio Aparecido Ignácio, Lucia de Noronha, Mariana Hornung Marins and 3 more

Abstract read
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Article in Odontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Arieli Carini MichelsPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Suelen Teixeira ScheiferPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Fernanda TiboniPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Filipe ModoloUniversidade Federal de Santa Catarina, Eng. Agronômico Andrei Cristian Ferreira, S/N - Trindade, Florianópolis, SC, 88040-900, Brazil.
Emanuela Carla Dos SantosPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Rafaela ScariotUniversidade Federal Do Paraná. Avenida Pref. Lothário Meissner, 632, Jardim Botânico, Curitiba, PR, 80210-170, Brazil.
Maria Cassia Ferreira AguiarUniversidade Federal de Minas Gerais. Avenida Presidente Antonio Carlos, 6627 - Pampulha, Belo Horizonte, MG, 31270-901, Brazil.
Sergio Aparecido IgnácioPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Lucia de NoronhaPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Mariana Hornung MarinsPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Bruno Correia JhamCollege of Dental Medicine - Illinois Midwestern University, 555 31St Street, Cardinal Hall, Room 594, Downers Grove, IL, 60515, USA.
Cleber Machado de SouzaPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil.
Aline Cristina Batista Rodrigues JohannPontifícia Universidade Católica Do Paraná. Imaculada Conceição, 1155, Prado Velho, Curitiba, PR, 80215-901, Brazil. aline.johann@pucpr.br.ORCID http://orcid.org/0000-0002-1678-9363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the association of NANOG polymorphisms with oral leukoplakia. In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson's chi-squared and Fisher's exact statistical tests were used, with a significance of 5%. For the dominant genetic model of the G allele of rs877716, the genotypes AG + GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75,4 and 50% respectively; p = 0,031). Subjects with this genotype were 3,063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7, 5% respectively; p = 0, 01). There was no association found in the other genetic models. Polymorphisms in NANOG are associated with oral leukoplakia.

Indexed as

Homeodomain ProteinsLeukoplakia, OralNanog Homeobox ProteinPolymorphism, Single NucleotideAdultAllelesCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedReal-Time Polymerase Chain ReactionHomeodomain ProteinsNanog Homeobox ProteinNANOG protein, humanEmbryonic stem cellsGenetic polymorphismNanog homeobox proteinOral leukoplakia

Identifiers

PMID39714583

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.