Evidence map›Paper›PMID 39715791›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2025

24-hour isolated aortic systolic hypertension phenotype and its association with carotid and cardiac damage: the SAFAR study.

Elpida Athanasopoulou, Fotios Karachalias, Lazaros Yofoglu, Panagiotis Kanatas, Kathrin Danninger, Thomas Weber, Jacques Blacher, Theodoros G Papaioannou, Efstathios Manios, Petros P Sfikakis and 2 more

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Elpida AthanasopoulouCardiovascular Prevention & Research Unit, Clinic/Laboratory of Pathophysiology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Fotios KarachaliasCardiovascular Prevention & Research Unit, Clinic/Laboratory of Pathophysiology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Lazaros YofogluCardiovascular Prevention & Research Unit, Clinic/Laboratory of Pathophysiology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis KanatasCardiovascular Prevention & Research Unit, Clinic/Laboratory of Pathophysiology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Kathrin DanningerCardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria.
Thomas WeberCardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria.
Jacques BlacherUniversité Paris Cité, Hôpital Hôtel-Dieu, Centre de diagnostic et de thérapeutique, Paris, France.
Theodoros G PapaioannouDepartment of Biomedical Engineering, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Efstathios ManiosDepartment of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Petros P Sfikakis1st department of Propaedeutic Internal Medicine, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Antonios A Argyris *Cardiovascular Prevention & Research Unit, Clinic/Laboratory of Pathophysiology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Athanase D Protogerou *Cardiovascular Prevention & Research Unit, Clinic/Laboratory of Pathophysiology, Laiko Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. aprotog@med.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of systolic hypertension phenotypes based on simultaneous 24-h brachial (br) and aortic (ao) ambulatory blood pressure monitoring (ABPM) remains unknown. We sought to describe their prevalence and associations with hypertension mediated organ damage (HMOD). Participants with 24-h br and ao ABPM, carotid ultrasound and echocardiography data were categorized into 4 systolic hypertension phenotypes: sustained systolic br and ao normotension (SSN), isolated br systolic hypertension (IbrSH), isolated ao systolic hypertension (IaoSH) and sustained br and ao systolic hypertension (SSH). Different calibrations for peripheral waveforms and cut-offs for 24-h ao systolic pressure were applied. Out of 1024 participants with ABPM, 684 had carotid and 423 echocardiography data. IaoSH ranged from 3.7% to 23.0% of the population, depending on the calibration and the applied cut-off; (SSN: 37.0-56.3%, IbrSH: 0.6-9.5%, SSH: 30.5-39.4%). In adjusted models including diastolic pressure, in comparison with SSN and IbrSH, IaoSH phenotype by 90

Indexed as

AortaCarotid ArteriesHypertensionAdultAgedBlood PressureBlood Pressure Monitoring, AmbulatoryEchocardiographyFemaleHumansHypertrophy, Left VentricularIsolated Systolic HypertensionMaleMiddle AgedPhenotypePrevalenceAmbulatory blood pressure monitoringAortic blood pressureBlood pressure phenotypesHypertension mediated organ damageIsolated aortic systolic hypertension

Identifiers

PMID39715791

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.