Evidence map›Paper›PMID 39716235›Full record

ArticleVirology journal2024

Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu.

Xingpei Ji, Ruyue Liang, Chao Bao, Xiuli Cai, Shiyao Chen, Lu Chen, Li Li, Xiaolei Ji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingpei Ji *Key Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Ruyue Liang *Key Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Chao BaoKey Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Xiuli CaiKey Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Shiyao ChenKey Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Lu ChenKey Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Li LiKey Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Xiaolei JiKey Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China. ntcdcjxl@outlook.com.

Funding

Xiaolei Ji JCZ2022117
6 · The paper itself

Abstract

Monkeypox (MPOX) is a zoonotic disease caused by Orthopoxvirus monkeypox (MPXV), belonging to the Orthopoxvirus genus, and exhibits symptoms similar to smallpox. In 2024, the monkeypox outbreak in the Democratic Republic of the Congo continued to develop, raising widespread global public health concerns. In September 2023, the first local monkeypox outbreak was reported in Nantong, Jiangsu Province, China. Whole-genome sequencing of samples from seven confirmed patients identified a new lineage, C.1.1, which may be related to imported cases from Japan. Evolutionary analysis of MPXV showed fewer mutations mediated by Apolipoprotein B mRNA Editing Catalytic polypeptide-like 3 (APOBEC3). Additionally, mutations in the N2L protein disrupted transcription initiation, while changes in the Cytomegalovirus-encoded immunomodulatory protein B (CrmB) led to structural instability of the protein. It is hoped that these findings will provide insights for future research on the evolutionary mechanisms of the monkeypox virus and the development of vaccines.

Indexed as

Evolution, MolecularMonkeypox virusMpox, MonkeypoxPhylogenyChinaDisease OutbreaksGenetic VariationGenome, ViralHumansMutationViral ProteinsWhole Genome SequencingViral ProteinsAPOBEC3Monkeypox virusPhylogenetic analysisSingle nucleotide polymorphism

Identifiers

PMID39716235
PMCPMC11665207

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.