Evidence mapPaperPMID 39716257Full record

ReviewBiomarker research2024

Decoding burn trauma: biomarkers for early diagnosis of burn-induced pathologies.

Fadi Khalaf, Daniella Touma, Alexandra Pappas, Lareina Hatim, Stephanie Wojtowicz-Piotrowski, Marc G Jeschke

Abstract readReview
In one paragraph

Review in Biomarker research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Longitudinal biomarker trajectories and their prognostic utility for 21-day mortality in burn patients with sepsis: a retrospective cohort study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  7. Article
  8. Sepsis in burn care: incidence and outcomes.Military Medical Research · 2025
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fadi Khalaf *David Braley Research Institute, Hamilton, ON, Canada.
Daniella Touma *David Braley Research Institute, Hamilton, ON, Canada.
Alexandra Pappas *David Braley Research Institute, Hamilton, ON, Canada.
Lareina Hatim *David Braley Research Institute, Hamilton, ON, Canada.
Stephanie Wojtowicz-PiotrowskiDavid Braley Research Institute, Hamilton, ON, Canada.
Marc G JeschkeDavid Braley Research Institute, Hamilton, ON, Canada. jeschke@HHSC.CA.

Funding

Adverse outcomes of aged mice are associated with adipose tissue failure after burnR01AG080040 · NIA · HAMILTON HEALTH SCIENCES CORPORATION · PI Marc Gerhard Jeschke · 2023 to 2026
$1.3M
NIA NIH HHS R01 AG080040NIH HHS R01AG080040-01A1
6 · The paper itself

Abstract

Burn injuries represent a significant global challenge due to their multifaceted nature, characterized by a complex cascade of metabolic and immune dysfunction that can result in severe complications. If not identified and managed promptly, these complications can escalate, often leading to fatal outcomes. This underscores the critical importance of timely and precise diagnosis. Fortunately, biomarkers for burn-induced pathologies and outcomes have emerged as powerful diagnostic and prognostic tools. These biomarkers enable early diagnosis and intervention, facilitate risk assessment, support patient-specific treatment, monitoring of disease progression, and therapeutic efficacy, ultimately contributing to improved patient outcomes. However, while previous studies have provided valuable biomarkers for the detection of burn-induced pathologies, many of these were constrained by the techniques and sample sizes available at the time, which can limit the generalizability of the findings. This review highlights numerous biomarkers studied in the literature to date, underscoring the need to replicate these findings in more diverse and representative populations. It also emphasizes the importance of advancing research efforts to develop more efficient, accurate, and cost-effective approaches for integrating biomarkers into clinical practice.

Indexed as

BiomarkersBurnsComplicationsHypermetabolismImmunopathyInflammationMultiorgan damageSepsisThermal injury

Identifiers

PMID39716257
PMCPMC11668120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.