Evidence map›Paper›PMID 39716293›Full record

ArticleJournal of orthopaedic surgery and research2024

Association between polymorphisms of glucagon-like peptide-1 receptor gene and susceptibility to osteoporosis in Chinese postmenopausal women.

Xiaoxue Bao, Chang Liu, Huiming Liu, Yan Wang, Peng Xue, Yukun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoxue BaoDepartment of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Chang LiuDepartment of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Huiming LiuDepartment of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Yan WangDepartment of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Peng XueDepartment of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China.
Yukun LiDepartment of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, China. lykun_1962@163.com.

Funding

Government-Funded Clinical Medical Outstanding Talent Project ZF2023102Hebei Province Natural Science Foundation Precision Medicine Joint Fund Cultivation Project H2020206314National Natural Science Foundation of China 82170892Project Plan of Medical Science Research in Hebei Province 20221155
6 · The paper itself

Abstract

backgroundThe influence of the glucagon-like peptide-1 receptor (GLP-1R) on bone metabolism is well-established. However, it has been observed that single nucleotide polymorphisms (SNPs) in the GLP-1R gene can partially affect its function. Therefore, this study aims to investigate the association between SNPs in the GLP-1R gene and postmenopausal osteoporosis (PMOP) within the Chinese Han population.

methodsThis study employed a cross-sectional case-control design, recruiting a total of 152 participants, including 76 patients with osteoporosis (OP) (case group) and 76 healthy individuals (control group). Seven tag SNPs of GLP-1R were selected from the National Center of Biotechnology Information and Genome Variation Server. The association between GLP-1R polymorphisms and PMOP risk was assessed using different genetic models and haplotypes, while also exploring SNP-SNP and SNP-environment interactions.

resultsOur results showed that minor alleles A at rs3765468, A at rs3765467 and G at rs4714210 showed significant associations with an increased risk of OP. Individuals with rs3765468 AG-AA genotype and rs3765467 AG-AA genotype exhibited a significantly higher risk of PMOP. Moreover, haplotype analysis revealed a significant association of the GACACA haplotype on PMOP risk (P = 0.033). Additionally, a multiplicative interaction was observed between rs3765468 and rs3765467 that was associated with an increased risk of PMOP (P

conclusionsSpecific SNPs in the GLP-1R gene were linked to an increased risk of PMOP. This study improves our understanding of the genetic basis of PMOP in this population and suggests that genetic screening can identify individuals at risk for developing PMOP, enabling early prevention.

Indexed as

Genetic Predisposition to DiseaseGlucagon-Like Peptide-1 ReceptorOsteoporosis, PostmenopausalPolymorphism, Single NucleotideAgedCase-Control StudiesChinaCross-Sectional StudiesEast Asian PeopleFemaleGenetic Association StudiesHaplotypesHumansMiddle AgedGLP1R protein, humanGlucagon-Like Peptide-1 ReceptorBone mineral densityGlucagon-like peptide-1 receptorHaplotypePostmenopausal osteoporosisSingle-nucleotide polymorphism

Identifiers

PMID39716293
PMCPMC11667832

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.