Evidence map›Paper›PMID 39716878›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.

Zhe Li, Yijia Gao, Xingyu Chen, Lei Xu, Zhou Li, Renjie Chai

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Rational Design of Inner Ear Drug Delivery Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhe LiDepartment of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, 100081, China.
Yijia GaoDepartment of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, 100081, China.
Xingyu ChenDepartment of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, 100081, China.
Lei XuDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, 250022, China.
Zhou LiBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Renjie ChaiDepartment of Neurology, Aerospace Center Hospital, School of Life, Beijing Institute of Technology, Beijing, 100081, China.ORCID https://orcid.org/0000-0002-3885-543X

Funding

Beijing Natural Science Foundation L212010Beijing Natural Science Foundation Z200019Fundamental Research Funds for the Central UniversitiesNational Key Research and Development Program 2020YFA0112503National Key Research and Development Program 2021YFA1101300National Key Research and Development Program 2021YFA1101800National Key Research and Development Program 2021YFB3200303National Key Research and Development Program 2022YFB3804700National Natural Science Foundation of China 82030029National Natural Science Foundation of China 82071053National Natural Science Foundation of China 82202348National Natural Science Foundation of China 82330033National Natural Science Foundation of China 92149304National Natural Science Foundation of China T2125003Natural Science Foundation of Jiangsu Province BK20232007Open Project Fund of Guangdong Academy of Medical Sciences YKY-KF202201Science and Technology Department of Sichuan Province 2021YFS0371Shenzhen Fundamental Research Program JCYJ20190814093401920Shenzhen Fundamental Research Program JCYJ20210324125608022Taishan Scholars Project-Young Experts Program of Shandong Province tsqn202211357
6 · The paper itself

Abstract

The World Health Organization (WHO) reports that by 2050, nearly 2.5 billion people are expected to have some degree of hearing loss (HL) and at least 700 million will need hearing rehabilitation. Therefore, there is an urgent need to develop treatment strategies for HL. At present, the main treatment strategies for HL are hearing aids and cochlear implants (CIs), which cannot achieve a radical cure for HL. Relevant studies have shown that the most fundamental treatment strategy for sensorineural hearing loss (SNHL) is to regenerate hair cells and spiral ganglion neurons (SGNs) through stem cells to repair the structure and function of cochlea. In addition, physical stimulation strategies, such as electricity, light, and magnetism have also been used to promote SGN regeneration. This review systematically introduces the classification, principle and latest progress of the existing hearing treatment strategies and summarizes the advantages and disadvantages of each strategy. The research progress of physical regulation mechanism is discussed in detail. Finally, the problems in HL repair strategies are summarized and the future development direction is prospected, which could provide new ideas and technologies for the optimization of hearing treatment strategies and the research of SGN repair and regeneration through physical regulation.

Indexed as

Hearing LossHearing Loss, SensorineuralNerve RegenerationRegenerationSpiral GanglionAnimalsCochlear ImplantsHair Cells, AuditoryHumanshearing lossesphysical regulationsregenerationsspiral ganglion neurons

Identifiers

PMID39716878
PMCPMC11791950

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.