ArticleBioactive materials2025
3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Bioelectric signals promote diabetic bone regeneration through Piezo1-mediated activation of the efferocytic immune microenvironment.Bioactive materials · 2026Article
- Engineered Nature-Based Sonosensitizer for Broad-Spectrum Infectious Tissue Repair via Sono-Ionic Therapy.Exploration (Beijing, China) · 2026Article
- Advances in 3D Printed Bone Implants: Smart Responsive Antibacterial Strategies and AI-Driven Design.Biomimetics (Basel, Switzerland) · 2026Review
- Biomass-Derived Hydrogels for Load-Bearing Connective Tissue Repair: Integrative Reinforcement, Bio-Functional Design, and Emerging Pathways Toward Clinical Translation.Advanced healthcare materials · 2026Review
- A promising therapeutic biomaterial: CHX@ZnO-HA/PSSS nanocomposites enable pH-Dependent infection eradication and bone regeneration in osteomyelitis.Journal of Taibah University Medical Sciences · 2026Article
- Dual-Strategy Design of Heterojunction-Enhanced Piezoelectric Hydrogels for Periodontitis Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Piezoelectric scaffold with enhanced effect drives the healing of osteochondral defects through electromechanical-immune coupling.Journal of nanobiotechnology · 2026Article
- 3D printed flexible composite scaffold with ultrasonic-driven wireless electrical stimulation promotes neuro-vascularization for critical-size bone defects regeneration.Bioactive materials · 2026Article
- Construction of chiral ZnO/BMP-2 dual functional coating on the surface of Ti implants for anti-infection and enhancement of osseointegration.Frontiers in bioengineering and biotechnology · 2026Article
- Sono-piezoelectric cues regulate neuroinflammatory reflex-arc-mediated α7nAChR-P2RX7 axis to dampen osteoarthritis-correlated pain with osteoarthritis attenuation.Theranostics · 2026Article
- Innovative 3D-printed porous piezoelectric poly(vinylidene fluoride) cages with accelerated spinal fusion.Materials today. Bio · 2025Article
- Electrosensitive Heterogeneous Short Fibers via Acousto-Electric Coupling for Sequential Bone Regeneration in Infectious Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Strategic advances in Vat Photopolymerization for 3D printing of calcium phosphate-based bone scaffolds: A review.Bioactive materials · 2025Review
- Schottky engineering of GDYO@Pt to boost piezoelectric and oxidative stress modulation for accelerated cranial regeneration.Nature communications · 2025Article
- Nanomaterial-based scaffolds for bone regeneration with piezoelectric properties.Nanomedicine (London, England) · 2025Review
- 3D bioprinted piezoelectric hydrogel synergized with LIPUS to promote bone regeneration.Materials today. Bio · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinically, infectious bone defects represent a significant threat, leading to osteonecrosis, severely compromising patient prognosis, and prolonging hospital stays. Thus, there is an urgent need to develop a bone graft substitute that combines broad-spectrum antibacterial efficacy and bone-inductive properties, providing an effective treatment option for infectious bone defects. In this study, the precision of digital light processing (DLP) 3D printing technology was utilized to construct a scaffold, incorporating zinc oxide nanoparticles (ZnO-NPs) modified barium titanate (BT) with hydroxyapatite (HA), resulting in a piezoelectric ceramic scaffold designed for the repair of infected bone defects. The results indicated that the addition of ZnO-NPs significantly improved the piezoelectric properties of BT, facilitating a higher HA content within the ceramic scaffold system, which is essential for bone regeneration. In vitro antibacterial assessments highlighted the scaffold's potent antibacterial capabilities. Moreover, combining the synergistic effects of low-intensity pulsed ultrasound (LIPUS) and piezoelectricity, results demonstrated that the scaffold promoted notable osteogenic and angiogenic potential, enhancing bone growth and repair. Furthermore, transcriptomics analysis results suggested that the early growth response-1 (EGR1) gene might be crucial in this process. This study introduces a novel method for constructing piezoelectric ceramic scaffolds exhibiting outstanding osteogenic, angiogenic, and antibacterial properties under the combined influence of LIPUS, offering a promising treatment strategy for infectious bone defects.
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