Evidence map›Paper›PMID 39717386›Full record

ArticleMechanobiology in medicine2024

Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields.

M Ete Chan, Christopher Ashdown, Lia Strait, Sishir Pasumarthy, Abdullah Hassan, Steven Crimarco, Chanpreet Singh, Vihitaben S Patel, Gabriel Pagnotti, Omor Khan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mechanobiology in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

M Ete ChanDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Christopher AshdownDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Lia StraitDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Sishir PasumarthyDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Abdullah HassanDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Steven CrimarcoDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Chanpreet SinghDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Vihitaben S PatelDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Gabriel PagnottiDepartment of Endocrine Neoplasia and Hormonal Disorders, MD Anderson Cancer Center, Houston, TX, 77030, USA.
Omor KhanDepartment of Mechanical and Biomedical Engineering, College of Engineering, Boise State University, Boise, ID, 83725-205, USA.
Gunes UzerDepartment of Mechanical and Biomedical Engineering, College of Engineering, Boise State University, Boise, ID, 83725-205, USA.
Clinton T RubinDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.

Funding

VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OCHOA-REPARAZ, JAVIER · 2014 to 2023
$22.7M
Establishing a Long Island Bioscience HubU01HL127522 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI RUBIN, CLINTON T · 2015 to 2017
$3.0M
Role of LINC-mediated Mechanosignaling in MSC AgingR01AG059923 · NIA · BOISE STATE UNIVERSITY · PI UZER, GUNES · 2020 to 2024
$1.6M
Harnessing mechanical signals to control mesenchymal stem cell fateR01EB014351 · NIBIB · STATE UNIVERSITY NEW YORK STONY BROOK · PI JUDEX, STEFAN, RUBIN, CLINTON T · 2012 to 2014
$1.0M
Live Cell Imaging System for Biomechanics and Mechanobiology ResearchS10OD032354 · OD · BOISE STATE UNIVERSITY · PI UZER, GUNES · 2022 to 2022
$233k
NHLBI NIH HHS U01 HL127522NIA NIH HHS R01 AG059923NIBIB NIH HHS R01 EB014351NIGMS NIH HHS P20 GM109095NIH HHS S10 OD032354
6 · The paper itself

Abstract

Biomanufacturing relies on living cells to produce biotechnology-based therapeutics, tissue engineering constructs, vaccines, and a vast range of agricultural and industrial products. With the escalating demand for these bio-based products, any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the discipline. While these goals are primarily achieved using

Indexed as

Adherent cellsBiomanufacturingBiomechanicsCell proliferationMechanical stimulationStem cellsSuspension cellsVibration

Identifiers

PMID39717386
PMCPMC11666124

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.