Evidence mapPaperPMID 39717474Full record

ArticleEuropean journal of radiology open2024

Multidisciplinary quantitative and qualitative assessment of IDH-mutant gliomas with full diagnostic deep learning image reconstruction.

Christer Ruff, Paula Bombach, Constantin Roder, Eliane Weinbrenner, Christoph Artzner, Leonie Zerweck, Frank Paulsen, Till-Karsten Hauser, Ulrike Ernemann, Georg Gohla

Abstract read
In one paragraph

Article in European journal of radiology open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christer RuffDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls-University Tuebingen, Tuebingen D-72076, Germany.
Paula BombachDepartment of Neurology and Interdisciplinary Neuro-Oncology, University Hospital Tuebingen, Tuebingen D-72076, Germany.
Constantin RoderCenter for Neuro-Oncology, Comprehensive Cancer Center Tuebingen-Stuttgart, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Tuebingen D-72070, Germany.
Eliane WeinbrennerDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls-University Tuebingen, Tuebingen D-72076, Germany.
Christoph ArtznerDepartment of Diagnostic and Interventional Radiology, Diakonie Klinikum Stuttgart, Stuttgart D-70176, Germany.
Leonie ZerweckDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls-University Tuebingen, Tuebingen D-72076, Germany.
Frank PaulsenDepartment of Radiation Oncology, University Hospital Tuebingen, Tuebingen D-72076, Germany.
Till-Karsten HauserDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls-University Tuebingen, Tuebingen D-72076, Germany.
Ulrike ErnemannDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls-University Tuebingen, Tuebingen D-72076, Germany.
Georg GohlaDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls-University Tuebingen, Tuebingen D-72076, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: This study explores the feasibility of deep learning-based reconstruction (DLR) in MRI for IDH-mutant gliomas. The research utilizes a multidisciplinary approach, engaging neuroradiologists, neurosurgeons, neuro-oncologists, and radiotherapists to evaluate qualitative aspects of DLR and conventional reconstructed (CR) sequences. Furthermore, quantitative image quality and tumor volumes according to Response Assessment in Neuro-Oncology (RANO) 2.0 standards were assessed. Results: All DLR sequences consistently outperformed CR sequences (median of 4 for all) in qualitative image quality across all raters (p < 0.001 for all) and revealed higher SNR and CNR values (p < 0.001 for all). Preference for all DLR over CR was overwhelming, with ratings of 84 % from the neuroradiologist, 100 % from the neurosurgeon, 92 % from the neuro-oncologist, and 84 % from the radiation oncologist. The RANO 2.0 compliant measurements showed no significant difference between the CR and DRL sequences (p = 0.142). Conclusion: This study demonstrates the clinical feasibility of DLR in MR imaging of IDH-mutant gliomas, with significant time savings of 29.6 % on average and non-inferior image quality to CR. DLR sequences received strong multidisciplinary preference, underscoring their potential for enhancing neuro-oncological decision-making and suitability for clinical implementation.

Indexed as

Deep learningDiagnostic accuracyIDH-mutant gliomasImage reconstructionMagnetic resonance imagingMultidisciplinaryVisual perception preference

Identifiers

PMID39717474
PMCPMC11664152

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.