Evidence map›Paper›PMID 39717754›Full record

ArticlemicroLife2024

Did organs precede organisms in the origin of life?

Fernando Baquero, Gabriel S Bever, Victor de Lorenzo, Val Fernández-Lanza, Carlos Briones

Abstract read
In one paragraph

Article in microLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fernando BaqueroDivision of Biology and Evolution of Microorganisms, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.ORCID https://orcid.org/0000-0002-7930-3033
Gabriel S BeverCenter for Functional Anatomy & Evolution, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
Victor de LorenzoSystems Biology Department, Centro Nacional de Biotecnologia, CSIC, 28049 Madrid-Cantoblanco, Spain.ORCID https://orcid.org/0000-0002-6041-2731
Val Fernández-LanzaDivision of Biology and Evolution of Microorganisms, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.
Carlos BrionesDepartment of Molecular Evolution, Centro de Astrobiología (CAB), CSIC-INTA, Torrejón de Ardoz,28864 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evolutionary processes acting on populations of organized molecules preceded the origin of living organisms. These prebiotic entities were independently and repeatedly produced [i.e. (re)-produced] by the assembly of their components, following an iterative process giving rise to nearly but not fully identical replicas, allowing for a prebiotic form of Darwinian evolution. Natural selection favored the more persistent assemblies, some possibly modifying their own internal structure, or even their environment, thereby acquiring function. We refer to these assemblies as proto-organs. In association with other assemblies (e.g. in a coacervate or encapsulated within a vesicle), such proto-organs could evolve and acquire a role within the collective when their coexistence favored the selection of the ensemble. Along millions of years, an extraordinarily small number of successful combinations of those proto-organs co-occurring in spatially individualizing compartments might have co-evolved forming a proto-metabolic and proto-genetic informative network, eventually leading to the selfreplication of a very few. Thus, interactions between encapsulated proto-organs would have had a much higher probability of evolving into proto-organisms than interactions among simpler molecules. Multimolecular forms evolve functions; thus, functional organs would have preceded organisms.

Indexed as

molecular evolutionorganismsorgansorigin of lifeproto-organsreproduction

Identifiers

PMID39717754
PMCPMC11664216

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.