ReviewFrontiers in immunology2024
Crosstalk between periodontitis and cardiovascular risk.
Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).Molecular medicine reports · 2026Review
- Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects.iMeta · 2026Review
- Multi-domain identification of myocardial infarction incidence using explainable AI: the overlooked role of periodontal health.Scientific reports · 2026Article
- Study on the Effect and Mechanism of the Outer Membrane Vesicles ofMicroorganisms · 2026Article
- The therapeutic potential of local injection of leptin for periodontitis in rats: an investigation based on the OPG/RANKL mechanism.BMC oral health · 2026Article
- The oral-vascular axis: immune mechanisms linking periodontal dysbiosis to systemic vascular pathology.Frontiers in immunology · 2026Review
- Periodontal Disease and Risk of Heart Failure: A Systematic Review and Meta-Analysis.International journal of dentistry · 2026Article
- Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis.Frontiers in immunology · 2026Review
- Comparative analysis of the microbiota in gingival crevicular fluid from peri-implantitis and periodontitis using 16 S ribosomal RNA gene amplicon sequencing: a cross-sectional study.BMC oral health · 2025Article
- A Clinical Review of the Connections Between Diabetes Mellitus, Periodontal Disease, and Cardiovascular Pathologies.Biomedicines · 2025Review
- Article
- Quantitative Evaluation of Postural SmartVest's Multisensory Feedback for Affordable Smartphone-Based Post-Stroke Motor Rehabilitation.International journal of environmental research and public health · 2025Article
- Potential diagnostic markers and therapeutic targets for periodontitis with comorbid infective endocarditis based on bioinformatics and experimental analyses.Frontiers in cell and developmental biology · 2025Article
- Oral microbiota in cardiovascular health and disease.Frontiers in cellular and infection microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its significant economic burden. Periodontal disease, an oral bacterial-induced inflammatory disease of tooth-supporting tissue, is regulated in its prevalence and severity by the individual host response to a dysbiotic oral microbiota. Clinically, both NCDs are highly associated; however, shared risk factors such as smoking, obesity, type II diabetes mellitus and chronic stress represent only an insufficient explanation for the multifaceted interactions of both disease entities. Specifically, the crosstalk between both diseases is not yet fully understood. This review summarizes current knowledge on the clinical association of periodontitis and CVD, and elaborates on how periodontitis-induced pathophysiological mechanisms in patients may contribute to increased cardiovascular risk with focus on atherosclerosis. Clinical implications as well as current and future therapy considerations are discussed. Overall, this review supports novel scientific endeavors aiming at improving the quality of life with a comprehensive and integrated approach to improve well-being of the aging populations worldwide.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.