ArticleAging cell2025
Associations of clinical parameter-based accelerated aging, genetic predisposition with risk of chronic kidney disease and associated life expectancy: A prospective cohort study.
Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Accelerated biological aging, genetic susceptibility, and lifestyle in relation to abdominal aortic aneurysm: A prospective study.The journal of nutrition, health & aging · 2026Article
- A machine learning-derived biological age model for liver grafts provides a superior assessment of aging compared to chronological age in transplantation.Scientific reports · 2026Article
- Early-life exposures, biological age acceleration, and type 2 diabetes in adulthood: mediation analyses in the UK Biobank.GeroScience · 2026Article
- Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade.GeroScience · 2026Article
- Liver-specific phenotypic aging, behavior and genetic risks, and long-term liver-related outcomes.GeroScience · 2026Article
- Liver-specific phenotypic aging, behavior and genetic risks, and long-term liver-related outcomes.GeroScience · 2026Article
- Commentary on "Accelerated biological aging and postoperative acute kidney injury in surgical patients".International journal of surgery (London, England) · 2026Article
- Comment on "Accelerated biological aging and postoperative acute kidney injury in surgical patients: a retrospective multicentre cohort analysis of 94,006 cases".International journal of surgery (London, England) · 2025Article
- Proteomics mediates the effects of biological aging on the progression of cardio-renal-metabolic comorbidity: a UK biobank cohort study.Cardiovascular diabetology · 2025Article
- Association Between Inflammatory Dietary Pattern and Cardiovascular-Kidney-Metabolic Syndrome: A Population-Based Study.Current medical science · 2025Article
- Associations of accelerated biological aging with intraoperative hypotension in major surgery: a multicenter cohort study of 116,996 patients.Annals of medicine · 2025Article
- Accelerated Biological Aging, Genetic Susceptibility, and the Risk of Abdominal Aortic Aneurysm: A Prospective Cohort Study.Reviews in cardiovascular medicine · 2025Article
- The Association Between Accelerated Biological Aging and the Physical, Psychological, and Cognitive Multimorbidity and Life Expectancy: Cohort Study.Aging cell · 2025Article
- Biological Age Acceleration Associated with the Progression Trajectory of Cardio-Renal-Metabolic Multimorbidity: A Prospective Cohort Study.Nutrients · 2025Article
- Article
- Associations between Life's Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Little evidence exists regarding the associations between clinical parameter-based biological aging and the incidence and outcome of chronic kidney disease (CKD). Thus, we aimed to assess the associations between biological aging, genetic risk, and the risk of CKD, as well as investigate the impact of accelerated biological aging on life expectancy. 281,363 participants free of kidney diseases from the UK Biobank were included in this prospective study. Biological age was measured from clinical traits using the KDM-BA and PhenoAge algorithms, and the discrepancies from chronological age were defined as biological age accelerations. A polygenic score was calculated to indicate the genetic predisposition of the estimated glomerular filtration rate (eGFR). A cause-specific competing risk model was used to estimate hazard ratios (HRs) and the corresponding confidence intervals (CIs) of incident CKD. We found that individuals with more pronounced accelerations in biological age exhibited an elevated risk of developing CKD (HR
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