ReviewThe lancet. Healthy longevity2024
Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations.
Abstract readReview
In one paragraph
Review in The lancet. Healthy longevity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Late-life body mass index and amyloid interaction on cognitive decline in unimpaired older adults.The journal of prevention of Alzheimer's disease · 2026Trial
- The Kidney-Brain Axis in Chronic Kidney Disease: Uremic Toxins, Cognitive Decline, Mechanistic Pathways, Biomarkers and Therapeutic Perspectives.Biomedicines · 2026Review
- Advancing brain health and dementia research in Canada: insights from focus groups with the Dementia Research and Innovation Funders Alliance.The Gerontologist · 2026Article
- Speech-based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of the Lifestyle for Brain Health (LIBRA) index with cognitive functioning across adulthood: Variation by sex and socioeconomic status in the German National Cohort (NAKO).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sociodemographic differences in dementia prevention knowledge in Germany: Implications for targeted health communication.The journal of prevention of Alzheimer's disease · 2026Article
- Exposome-wide patterns predict brain health in aging.Nature communications · 2026Article
- "Brain health"-the emergence of a new healthy construct and its role in everyday life.The Gerontologist · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Social disadvantage outweighs knowledge in dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Involving Societal Stakeholders in Dementia Risk Reduction: An Explorative Study.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Transdisciplinary fetal-neonatal neurology training integrates women's and children's health with life-course brain capital strategies: a narrative review.Frontiers in neurology · 2026Review
- Tauroursodeoxycholic Acid Inhibits NF-κB/p300/H3K14ac to Attenuate Microglial Activation in Lipopolysaccharide-treated BV-2 Cells and Mice.Molecular neurobiology · 2025Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
- Intention to use and perceived satisfaction with a digital tool for dementia prevention among the Dutch general public: a cross-sectional study.BMC public health · 2025Observational
- The exposome of healthy and accelerated aging across 40 countries.Nature medicine · 2025Article
- Shared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise.Journal of neurochemistry · 2025Review
- Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Francesca R FarinaPritzker School of Medicine, The University of Chicago, Chicago, IL, USA; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. Electronic address: francesca.farina@gbhi.org.
Katie BridgemanEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Sarah GregoryEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Scottish Brain Sciences, Edinburgh, UK.
Lucía CrivelliFleni, Montañeses, Buenos Aires, Argentina.
Isabelle F FooteInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Otto-Emil I JutilaAlzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Ludmila KucikovaSchool of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Luciano I MarianoGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland; Cognitive and Behavioural Neurology Group (Clinical Hospital) and Neuroscience Program (Institute of Biological Sciences), Federal University of Minas Gerais, Belo Horizonte, Brazil.
Kim-Huong NguyenGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland; Centre for Health Services Research, School of Public Health, The University of Queensland, Brisbane, QLD, Australia.
Tony ThayanandanDepartment of Psychiatry, University of Oxford, Oxford, UK.
Funmi AkindejoyeGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, Australia.
Joe ButlerSchool of Psychology, University of Sunderland, Sunderland, UK.
Ismael L CalandriFleni, Montañeses, Buenos Aires, Argentina; Department of Neurology, Amsterdam Neuroscience, Alzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Giedrė ČepukaitytėInstitute of Cognitive Neuroscience, University College London, London, UK.
Scott T ChiesaInstitute of Cardiovascular Science, University College London, London, UK.
Walter D DawsonSchool of Medicine, Oregon Health & Science University, Portland, OR, USA; Institute on Aging, College of Urban and Public Affairs, Portland State University, Portland, OR, USA.
Kay DeckersSchool for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Vanessa De la Cruz-GóngoraGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland; National Institute of Public Health, Cuernavaca, Mexico.
Maria-Eleni DounaviDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Ishtar GoviaCaribbean Institute for Health Research, The University of West Indies, Kingston, Jamaica; Institute for Global Health, University College London, London, UK.
Edmarie Guzmán-VélezMassachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Shimaa A HeikalInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Tanisha G Hill-JarrettMemory and Aging Center, San Francisco, CA, USA; GBHI, University of California San Francisco, San Francisco, CA, USA.
Agustín IbáñezGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland; Latin America Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Bryan D JamesRush University Medical Center, Chicago, IL, USA.
Eimear McGlincheyGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
Donncha S MullinAlzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
Graciela Muniz-TerreraEdinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Social Medicine, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, USA.
Maritza Pintado CaipaGBHI, University of California San Francisco, San Francisco, CA, USA.
Esraa M QansuwaInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Louise RobinsonPopulation Health Sciences Institute, Newcastle University, Newcastle, UK.
Antonella Santuccione ChadhaWomen's Brain Foundation, Basel, Switzerland.
Oliver M ShannonPopulation Health Sciences Institute, Newcastle University, Newcastle, UK.
Li SuSchool of Medicine and Population Health, University of Sheffield, Sheffield, UK; Department of Psychiatry, University of Cambridge, Cambridge, UK.
Wendy WeidnerAlzheimer's Disease International, London, UK.
Laura BooiGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland; Centre for Dementia Research, School of Health, Leeds Beckett University, Leeds, UK.
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MARIA LUISA GORNO TEMPINI · 2002 to 2026
$67.2MResearch Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Lisa C Silbert · 2020 to 2026
$28.6MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MPilot CoreP30AG024978 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2004 to 2023
$9.0MAn automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MPredictors and consequences of the timing and accuracy of clinical dementia diagnosisR01AG072559 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Bryan David James · 2022 to 2026
$2.9MLEGENNDS: Linking Epidemiology and GEnetics of Neurodevelopmental and Neurodegenerative Disorders StudyR01NS131433 · NINDS · DREXEL UNIVERSITY · PI Brian Kane Lee · 2023 to 2026
$2.1MLarge-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetRF1AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2021 to 2021
$2.1MLarge-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetR01AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2024 to 2025
$1.3MAerobic fitness as a modifier of neurodegeneration and cognitive decline in preclinical Alzheimer's diseaseK23AG061276 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GUZMÁN-VÉLEZ, EDMARIE · 2019 to 2023
$881kStructural Gendered RacismK23AG084871 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tanisha G Hill-Jarrett · 2024 to 2026
$593kNIA NIH HHS K23 AG061276NIA NIH HHS K23 AG084871NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG024978NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG072559NIA NIH HHS R01 AG073593NIA NIH HHS R01 AG075775NIA NIH HHS RF1 AG073593NINDS NIH HHS R01 NS131433
Abstract
Efforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a neglected population in dementia research and policy making despite being highly exposed to several known modifiable risk factors. The risk and protective factors that have the biggest effect on dementia outcomes in young adulthood, and how these associations differ across regions and groups, still remain unclear. To address these uncertainties, the Next Generation Brain Health team convened a multidisciplinary expert group representing 15 nations across six continents. We identified several high-priority modifiable factors in young adulthood and devised five key recommendations for promoting brain health, ranging from individual to policy levels. Increasing research and policy focus on brain health across the life course, inclusive of younger populations, is the next crucial step in the efforts to prevent dementia at the global level.
Indexed as
DementiaGlobal HealthPublic HealthAdolescentAdultBrainHumansRisk FactorsYoung Adult
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.