Evidence map›Paper›PMID 39718599›Full record

Trial reportEuropean journal of nutrition2024

Long-term egg-protein hydrolysate consumption improves endothelial function: a randomized, double-blind, placebo-controlled trial in older adults with overweight or obesity.

Micah S Adams, Ronald P Mensink, Jogchum Plat, Bjorn Winkens, Peter J Joris

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04831203 (An Egg-protein Hydrolysate), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04831203 nacompletednot on this map

An Egg-protein Hydrolysate (NWT-03) to Boost Brain Function - Mind Your Blood Vessels

TypeinterventionalSponsorMaastricht University Medical CenterRan2021 to 2022Enrolled44ConditionsBrain Vascular Function, CognitionArmsAn egg-protein hydrolysate (NWT-03), Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Micah S AdamsDepartment of Nutrition and Movement Sciences, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, PO Box 616, 6200 MD, Maastricht, The Netherlands. m.adams@maastrichtuniversity.nl.ORCID http://orcid.org/0009-0003-9749-0404
Ronald P MensinkDepartment of Nutrition and Movement Sciences, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, PO Box 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-8908-3580
Jogchum PlatDepartment of Nutrition and Movement Sciences, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, PO Box 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-1570-9608
Bjorn WinkensDepartment of Methodology and Statistics, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center+, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-6747-6228
Peter J JorisDepartment of Nutrition and Movement Sciences, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Universiteitssingel 50, PO Box 616, 6200 MD, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-6852-5776

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe dietary egg-protein hydrolysate Newtricious (NWT)-03 has previously demonstrated improvements in blood pressure and metabolic profiles. However, the long-term effects on vascular function and cardiometabolic risk markers are unknown.

methodsForty-four older (aged 60-75) adults with overweight/obesity experiencing elevated Subjective Cognitive Failures (SCF) were randomized into a 36-week, double-blind, placebo-controlled trial. Participants either consumed 5.7 g of an egg-protein hydrolysate (NWT-03) or maltodextrin placebo. Endothelial function (brachial artery flow-mediated vasodilation [FMD] and carotid artery reactivity [CAR] responses after a cold pressor test), arterial stiffness (carotid-to-femoral pulse wave velocity [PWV

resultsFMD observed a non-significant trend towards a 0.3 percentage point (pp) increase in the intervention compared to the placebo group (95% CI: [0.0, 0.7]; p = 0.08), and a significant intervention effect was observed on CAR responses based on a 0.7 pp improvement after a cold pressor test (95% CI: [0.1, 1.3]; p = 0.03). No significant overall changes were observed for arterial stiffness as measured by PWV

conclusionLong-term supplementation with 5.7 g of the egg-protein hydrolysate NWT-03 for 36 weeks improved vascular endothelial function in older adults with overweight/obesity experiencing elevated SCF, which may benefit cardiovascular disease risk. No overall changes in other vascular function markers, retinal microvascular calibers or cardiometabolic risk markers were observed. CLINICAL

trial registrationThe study was registered at ClinicalTrials.gov in January 2021 as NCT04831203: https://clinicaltrials.gov/study/NCT04831203.

Indexed as

Endothelium, VascularObesityOverweightProtein HydrolysatesAgedBlood PressureDouble-Blind MethodEgg ProteinsFemaleHumansMaleMiddle AgedPulse Wave AnalysisVascular StiffnessVasodilationEgg ProteinsProtein HydrolysatesArterial stiffnessCardiometabolic risk markersEgg-protein hydrolysatesEndothelial functionRetinal microvascular calibersVascular function

Identifiers

PMID39718599

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.