Evidence map›Paper›PMID 39719480›Full record

ArticleCellular and molecular life sciences : CMLS2024

Maternal high glucose and fat diet exposure impaired vascular constriction via miR-325-3P/SHIP2/NOX2 pathway axis in offspring vessels.

Bingyu Ji, Fengying Deng, Bingqing Zhou, Chenxuan Zhao, Jiahui Lei, Ting Xu, Junlan Qiu, Meihua Zhang, Yueming Zhang, Minggang Wei and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bingyu Ji *Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Fengying Deng *Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Bingqing Zhou *Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Chenxuan ZhaoInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Jiahui LeiInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Ting XuInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Junlan QiuDepartment of Oncology and Hematology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, Jiangsu, 215153, People's Republic of China.
Meihua ZhangKey Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao University, Jinan, 250014, Shandong, China.
Yueming ZhangInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Minggang WeiDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. weiminggang2022@163.com.
Qinqin GaoInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. jennyqgao@126.com.ORCID http://orcid.org/0000-0002-1820-7611

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMaternal western-style diets that are high in glucose and fat have well-known cardiovascular effects on offspring, yet the combined influence of such diets during pregnancy is relatively less comprehended. This study investigates the impact of maternal high glucose and fat diet (HGF) on vascular constriction in offspring and the underlying mechanisms. METHODS AND

resultsPregnant Sprague-Dawley rats were provided with either HGF or control diets. The assessment of fetal and postnatal vascular function disclosed an enhanced sensitivity to angiotensin II-induced vascular constriction in the offspring exposed to HGF. This was ascribed to increased oxidative stress via upregulated NOX2 expression, which was due to downregulated SHIP2 expression that was influenced by upregulated miR-325-3p. The maternal HGF diet elevated miR-325-3p, suppressed SHIP2 and enhanced NOX2 expression in fetal vascular tissues, thereby resulting in vascular dysfunction. These alterations persist into adulthood, heightening the risk of vascular diseases.

conclusionThe present study is the first to demonstrate that maternal HGF diet impairs vascular constriction function in offspring through the miR-325-3p/SHIP2/NOX2 pathway. These novel findings indicate that the detrimental effects of maternal HGF diet on fetal vascular function can persist into adulthood, advancing our knowledge on the impact of maternal diet on offspring vascular health and the early stages of fetal-origin vascular diseases.

Indexed as

Diet, High-FatMicroRNAsNADPH Oxidase 2Oxidative StressRats, Sprague-DawleyAnimalsFemaleGlucoseMalePregnancyPrenatal Exposure Delayed EffectsRatsSignal TransductionVasoconstrictionCybb protein, ratGlucoseMicroRNAsNADPH Oxidase 2High glucose and fat dietsMiR-325-3p/SHIP2/NOX2 pathwayOffspringPregnancyVascular constriction

Identifiers

PMID39719480
PMCPMC11668719

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.