ArticleCommunications biology2024
mFusion: a multiscale fusion method bridging neuroimages to genes through neurotransmissions in mental health disorders.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Decoding the mechanisms of acupuncture by neuroimaging: an integrated review from networks to molecules.Frontiers in human neuroscience · 2026Review
- mFusion: a multiscale fusion method bridging neuroimages to genes through neurotransmissions in mental health disorders.Communications biology · 2024Article
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Authors and funding
4 authors.
Funding
Abstract
Mental health disorders emerge from complex interactions among neurobiological processes across multiple scales, which poses challenges in uncovering pathological pathways from molecular dysfunction to neuroimaging changes. Here, we proposed a multiscale fusion (mFusion) method to evaluate the relevance of each gene to the neuroimaging traits of mental health disorders. We combined gene-neuroimaging associations with gene-positron emission tomography (PET) and PET-neuroimaging associations using protein-protein interaction networks, where various genes traced by PET maps are involved in neurotransmission. Compared with previous methods, the proposed algorithm identified more disease genes on both simulated and empirical data sets. Applying mFusion to eight mental health disorders, we found that these disorders formed three clusters with distinct associated genes. In summary, mFusion is a promising tool of prioritizing genes for mental health disorders by establishing gene-PET-neuroimaging pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.