Evidence map›Paper›PMID 39720516›Full record

ArticleiScience2024

Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling.

Myra N Chávez, Prateek Arora, Marco Meer, Ines J Marques, Alexander Ernst, Rodrigo A Morales Castro, Nadia Mercader

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Myra N ChávezDepartment of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Prateek AroraDepartment of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Marco MeerDepartment of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Ines J MarquesDepartment of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Alexander ErnstDepartment of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Rodrigo A Morales CastroDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.
Nadia MercaderDepartment of Developmental Biology and Regeneration, Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy-lysosomal degradation is a conserved homeostatic process considered to be crucial for cardiac morphogenesis. However, both its cell specificity and functional role during heart development remain unclear. Here, we introduced zebrafish models to visualize autophagic vesicles

Indexed as

Cell biologyDevelopmental biologyModel organismMolecular biologyTranscriptomics

Identifiers

PMID39720516
PMCPMC11667069

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.