ReviewJACC. Advances2025
Mixed Cardiogenic-Vasodilatory Shock: Current Insights and Future Directions.
Review in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Trial
- Article
- Vasopressor-Associated Limb Ischemia Resulting in Quadruple Amputation in Suspected Septic Shock.Clinical case reports · 2026Article
- Vasoplegia in Cardiac Surgery and Mechanical Circulatory Support: From Cardiopulmonary Bypass to Advanced Circulatory Support Devices.Journal of cardiovascular development and disease · 2026Review
- Hemodynamic Effects of Anesthetics, Sedatives, and Analgesics in the CICU: Clinical Decision Guidance.JACC. Advances · 2026Review
- Persistent Intraoperative Shock and Acute Kidney Injury After Liver Transplantation.Journal of clinical medicine · 2026Article
- Influence of Sepsis on Clinical Outcomes During Mechanical Circulatory Support by Microaxial Flow Pump in Patients with Cardiogenic Shock Following Acute Myocardial Infarction.Journal of clinical medicine · 2026Article
- Leukocyte Ratios Associate With Vasodilatory Hemodynamics in Cardiac Intensive Care Shock.JACC. Advances · 2026Article
- CalShock: beyond the shock team, building on California's cardiogenic shock system of care.Heart failure reviews · 2026Article
- Cardiogenic Shock Detection Using Electronic Medical Records: A Review and Blueprint for Clinical Implementation and Future Research.Journal of the American Heart Association · 2026Review
- Timing of intervention in cardiogenic shock management: A systematic review and network meta-analysis.Journal of education and health promotion · 2026Review
- Electroacupuncture-inspired neuroimmune modulation in sepsis: evidence appraisal and ICU trial-design priorities.Frontiers in medicine · 2026Review
- A Proposed Algorithm for the Management of Patients with Cardiogenic Shock Based on Contemporary Knowledge and Gaps in Evidence.Journal of cardiovascular development and disease · 2025Review
- Cardiogenic shock in severe ARDS: the role of cardiorespiratory extracorporeal life support.Intensive care medicine · 2025Article
- Cardiogenic shock: a review of contemporary approaches and ongoing challenges.Future cardiology · 2025Review
- Contemporary Practice Patterns of Vasoactive Use in Cardiogenic Shock in the American Heart Association Cardiogenic Shock Registry.Journal of the American Heart Association · 2025Article
- Three-dimensional transesophageal echocardiography and speckle tracking echocardiography in left-sided native valve infective endocarditis: analysis of valvular and ventricular parameters predictors of outcome.The international journal of cardiovascular imaging · 2025Article
- Flow of Data, Not Blood Flow, Is the Key to Unraveling ECMO Support in Mixed Shock.JACC. Advances · 2025Article
- Fever in Myocardial Infarction-Related Cardiogenic Shock.JACC. Advances · 2025Article
- Clinical Characteristics and Outcomes of Patients Admitted in Cardiac Intensive Care Unit with Cardiogenic Shock: A Single-Center Study.Diseases (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This state-of-the-art review describes the potential etiologies, pathophysiology, and management of mixed shock in the context of a proposed novel classification system. Cardiogenic-vasodilatory shock occurs when cardiogenic shock is complicated by inappropriate vasodilation, impairing compensatory mechanisms, and contributing to worsening shock. Vasodilatory-cardiogenic shock occurs when vasodilatory shock is complicated by myocardial dysfunction, resulting in low cardiac output. Primary mixed shock occurs when a systemic insult triggers both myocardial dysfunction and vasoplegia. Regardless of the etiology of mixed shock, the hemodynamic profile can be similar, and outcomes tend to be poor. Identification and treatment of both the initial and complicating disease processes is essential along with invasive hemodynamic monitoring given the evolving nature of mixed shock states. Hemodynamic support typically involves a combination of inotropes and vasopressors, with few data available to guide the use of mechanical circulatory support. Consensus definitions and novel treatment strategies are needed for this dangerous condition.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.