Evidence map›Paper›PMID 39721719›Full record

ArticleWorld journal of surgery2025

Does a Restrictive Diagnostic Work-up for Thyroid Nodules Lead to a Different Papillary Thyroid Cancer Patient Population? A Comparison Between Dutch and U.S. T1-T3 Patient Population.

Maaike B C Ten Hoor, Jia F Lin, Madelon J H Metman, Pedro M Rodriguez Schaap, Thera P Links, Renske Altena, Tessa M van Ginhoven, Wouter T Zandee, Anton F Engelsman, Schelto Kruijff

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maaike B C Ten HoorDepartment of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0009-0004-3967-8027
Jia F LinDepartment of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Madelon J H MetmanDepartment of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Pedro M Rodriguez SchaapDepartment of Surgery, Amsterdam University Medical Centre, Location VUmc Cancer Centre Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-7541-6516
Thera P LinksDepartment of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Renske AltenaKarolinska Comprehensive Cancer Center, Karolinska University Hospital, Stockholm, Sweden.
Tessa M van GinhovenDepartment of Surgery, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands.
Wouter T ZandeeDepartment of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Anton F EngelsmanDepartment of Surgery, Amsterdam University Medical Centre, Location VUmc Cancer Centre Amsterdam, Amsterdam, the Netherlands.
Schelto KruijffDepartment of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe 2015 American Thyroid Association guidelines recommend de-escalating surgical treatment for papillary thyroid cancer (PTC). We hypothesize that the Dutch PTC population might differ due to a restrictive diagnostic policy that mainly selects symptomatic and palpable thyroid nodules for further diagnostics, potentially selecting relatively more aggressive tumors. We aimed to describe the Dutch PTC population because differences in populations can have consequences for the adoption of foreign guidelines.

methodsFrom the Dutch national cancer registry, patients diagnosed with pT1-T3 PTC between 2005 and 2015 were included. Baseline characteristics, disease-free interval, and overall survival were compared between low-risk and non-low risk PTC. Furthermore, the TNM stage of the Dutch and U.S. cohorts were compared via literature search.

resultsOf the 3368 pT1-T3 patients included, 1813 (53.8%) had a low-risk PTC, and 1555 (46.2%) had a non-low-risk PTC. In the Dutch PTC population, pT1 tumors occurred in 45.8%, pT2 and pT3 tumors occurred in 34.9% and 19.3% of the patients, respectively. Of all patients, 10.2% had central lymph node metastases and 16.6% had lateral lymph node metastasis. Distant metastasis only occurred in 18 (0.5%) of the patients. The 10-year overall survival was 89.6%, with rates of 91.6% for low-risk and 87.3% for non-low-risk patients (p = < 0.001). During the follow-up period, 257 patients (7.6%) had a recurrence. DISCUSSION: The higher frequency of advanced tumors among the Dutch PTC population in contrast to the U.S. emphasizes the need for careful national data analyses before the adoption of surgical intervention de-escalation protocols from other countries.

Indexed as

Lymphatic MetastasisNeoplasm Recurrence, LocalThyroid Cancer, PapillaryThyroid NeoplasmsThyroid NoduleAdultAgedDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleMedical OncologyMiddle AgedNeoplasm StagingNetherlands2015 ATA guidelinesde‐escalationpapillary thyroid carcinomathyroid cancertreatment

Identifiers

PMID39721719
PMCPMC11994149

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.