Evidence map›Paper›PMID 39722074›Full record

ArticleActa neuropathologica communications2024

A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G

Emily G Thompson, Olivia Spead, Suleyman C Akerman, Carrie Curcio, Benjamin L Zaepfel, Erica R Kent, Thomas Philips, Balaji G Vijayakumar, Anna Zacco, Weibo Zhou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Intrathecal (GActa neuropathologica communications · 2026
    Article
  2. Intrathecal (GbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Emily G Thompson *Brain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.
Olivia Spead *Brain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.
Suleyman C AkermanBrain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.ORCID 0000-0001-8424-1917
Carrie CurcioGlaxo Smith Kline Research and Development, 1250 S. Collegeville Road, Collegeville, PA, 19426, USA.
Benjamin L ZaepfelBrain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.
Erica R KentBrain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.
Thomas PhilipsBrain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.
Balaji G VijayakumarBrain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.
Anna ZaccoGlaxo Smith Kline Research and Development, 1250 S. Collegeville Road, Collegeville, PA, 19426, USA.
Weibo ZhouBrain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA.
Guhan NagappanGlaxo Smith Kline Research and Development, 1250 S. Collegeville Road, Collegeville, PA, 19426, USA.
Jeffrey D RothsteinBrain Science Institute, Johns Hopkins University School of Medicine, Johns Hopkins University, 855 N. Wolfe St., Rangos 275, Baltimore, MD, 21205, USA. jrothstein@jhmi.edu.

Funding

Nuclear and Glial Dysfunction in NeurodegenerationR35NS132179 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Jeffrey D Rothstein · 2023 to 2026
$4.9M
Role of Norrin in synaptic biology during development, adulthood, and diseaseF32NS120940 · NINDS · JOHNS HOPKINS UNIVERSITY · PI THOMPSON, EMILY G · 2021 to 2023
$83k
NINDS NIH HHS F32 NS120940NINDS NIH HHS R01 5R35NS132179NINDS NIH HHS R35 NS132179
6 · The paper itself

Abstract

The G

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinDisease Models, AnimalDNA-Binding ProteinsDNA Repeat ExpansionFrontotemporal DementiaMice, TransgenicAnimalsBehavior, AnimalDependovirusHumansMaleMiceMice, Inbred C57BLC9orf72 ProteinC9orf72 protein, humanC9orf72 protein, mouseDNA-Binding ProteinsTardbp protein, mouseAmyotrophic lateral sclerosisC9orf72 repeat expansionDipeptide repeatsGFAPNfLP62

Identifiers

PMID39722074
PMCPMC11670477

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.