Evidence map›Paper›PMID 39722151›Full record

ArticleAdvanced healthcare materials2025

NIR-Light Activable 3D Printed Platform Nanoarchitectured with Electrospun Plasmonic Filaments for On Demand Treatment of Infected Wounds.

Daniel Rybak, Jingtao Du, Paweł Nakielski, Chiara Rinoldi, Alicja Kosik-Kozioł, Anna Zakrzewska, Haoyang Wu, Jing Li, Xiaoran Li, Yunlong Yu and 2 more

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  17. Nanomaterials for biomedical applications.Beilstein journal of nanotechnology · 2025
    Article
  18. Review
  19. Development of Rapid and Economic In Vitro Assay and Biorelevant Ex Vivo Biofilm Inhibition Wound Model to Test the Antibacterial Efficacy of Wound Dressings.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel RybakDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.
Jingtao DuInnovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai, 201620, P. R. China.
Paweł NakielskiDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.
Chiara RinoldiDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.
Alicja Kosik-KoziołDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.
Anna ZakrzewskaDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.
Haoyang WuInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, P. R. China.
Jing LiInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, P. R. China.
Xiaoran LiInnovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai, 201620, P. R. China.
Yunlong YuInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, P. R. China.
Bin DingInnovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai, 201620, P. R. China.
Filippo PieriniDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.ORCID 0000-0002-6526-4141

Funding

Narodowe Centrum Badań i Rozwoju WPC2/Nanohealer/2021National Center for Research and Development
6 · The paper itself

Abstract

Bacterial infections can lead to severe complications that adversely affect wound healing. Thus, the development of effective wound dressings has become a major focus in the biomedical field, as current solutions remain insufficient for treating complex, particularly chronic wounds. Designing an optimal environment for healing and tissue regeneration is essential. This study aims to optimize a multi-functional 3D printed hydrogel for infected wounds. A dexamethasone (DMX)-loaded electrospun mat, incorporated with gold nanorods (AuNRs), is structured into short filaments (SFs). The SFs are 3D printed into gelatine methacrylate (GelMA) and sodium alginate (SA) scaffold. The photo-responsive AuNRs within SFs significantly enhanced DXM release when exposed to near-infrared (NIR) light. The material exhibits excellent photothermal properties, biocompatibility, and antibacterial activity under NIR irradiation, effectively eliminating Staphylococcus aureus and Escherichia coli in vitro. In vivo, material combined with NIR light treatment facilitate infectes wound healing, killing S. aureus bacteria, reduced inflammation, and induced vascularization. The final materials' shape can be adjusted to the skin defect, release the anti-inflammatory DXM on-demand, provide antimicrobial protection, and accelerate the healing of chronic wounds.

Indexed as

Infrared RaysPrinting, Three-DimensionalWound InfectionAlginatesAnimalsAnti-Bacterial AgentsDexamethasoneEscherichia coliGelatinGoldHumansHydrogelsMiceNanotubesStaphylococcus aureusWound HealingAlginatesAnti-Bacterial AgentsDexamethasoneGelatinGoldHydrogels3D printinginfected wound healingNIR light‐responsiveplasmonic short‐filamentssmart drug delivery

Identifiers

PMID39722151
PMCPMC11874648

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.