ArticleOncology letters2025
Metastasis of clear cell renal cell carcinoma to hyalinizing trabecular tumor of the thyroid: A case report.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal cell carcinoma (RCC) is the most common malignancy that metastasizes to the thyroid; however, metastasis of RCC to a primary tumor of the thyroid is rare. The present study reports the case of RCC that had metastasized to the primary thyroid tumor; namely, a hyalinizing trabecular tumor (HTT). Notably, the RCC was resected 2 years prior. A 60-year-old female patient was referred to Ningbo Beilun District People's Hospital with radiographic findings indicating thyroid nodules. The patient's previous medical history included a left nephrectomy for the treatment of clear cell (cc)RCC in February 2021. No other distant metastases were identified as of the latest follow-up in April 2023. No abnormalities were observed during thyroid function tests prior to thyroid surgery. The surgical specimen appeared as a multinodular goiter with a solid nodule measuring 55×41×33 mm on the left lobe of the thyroid. Microscopic examination revealed a gray-yellow area inside the capsule of the largest nodule of the left lobe, which was composed of clear cells arranged in a solid pattern. Notably, tumor cells in other areas exhibited trabecular, nested and island patterns. Results of an immunohistochemical examination revealed that the clear cell lesion was negative for thyroid transcription factor-1 and calcitonin, and strongly positive for carbonic anhydrase IX, common acute lymphoblastic leukemia antigen and vimentin. To the best of our knowledge, the present study is the first to report a case of ccRCC that had metastasized to a HTT. A preliminary analysis of the potential mechanisms underlying ccRCC metastasis was performed. Following total thyroidectomy, the patient was treated with levothyroxine, underwent anti-programmed death-1 monoclonal antibody immunotherapy and small molecule tyrosine kinase inhibitor targeted therapy. An enhanced computed tomography scan revealed no evidence of metastatic disease to other organs. As of the latest follow-up, the patient was in a good condition with no sign of metastasis or recurrence.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.