ArticleFrontiers in bioengineering and biotechnology2024
Influence of acupuncture intensity on analgesic effects in AA rat models.
Article in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging evidence of acupuncture in cognitive impairment following ischemic stroke: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Clinical characteristics of acupoint sensitization in patients with essential hypertension: a cross-sectional matched case-control study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Mast cell degranulation mediates analgesic effects of acupuncture at different stimulation durations in arthritic rats.Integrative medicine research · 2025Article
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9 authors.
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Abstract
Objective: To investigate the influence of acupuncture lifting-thrusting frequency and amplitude on the analgesic effects, and its correlation with mast cell degranulation. Methods: Acute adjuvant arthritis (AA) rat models were employed. Robot-arm aided lifting-thrusting acupuncture therapy was conducted with various frequencies (ranging from 0.5 to 4 Hz) and amplitudes (ranging from 0.5 to 2.0 mm). The rats' pain thresholds were measured multiple times before and after the therapy, and the analgesic effects were evaluated using the pain threshold recovery rate (PTRR), a normalized index. The mast cell degranulation rate (MCdR) at the acupoint was calculated, and a correlation analysis between PTRR and MCdR was performed. Results: Acupuncture therapy partially restored the pain threshold affected by arthritis. The analgesic effects were influenced by stimulus frequency and amplitude, with best outcomes occurring at an intermediate optimal frequency of 1.0 Hz and amplitude of 1.0-1.5 mm. Similarly, the MCdR peaked at the optimal frequency and amplitude. Conclusion: Our animal experiment suggests that optimal analgesic effects can be achieved with stimulation at an optimal intensity. This intensity-effect correlation appears to originate from mast cell activation rates under different mechanical stimulus.
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