ArticleHypertension (Dallas, Tex. : 1979)2025
Chromatin State Maps of Blood Pressure-Relevant Renal Segments Reveal Potential Regulatory Role for SNPs.
Atrayee Ray, Chun Yang, Cary Stelloh, Monika Tutaj, Pengyuan Liu, Yong Liu, Qiongzi Qiu, Paul L Auer, Chien-Wei Lin, Michael E Widlansky and 6 more
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In one paragraphArticle in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
16 authors.
Atrayee RayVersiti Blood Research Institute, Milwaukee, WI (A.R., C.S., S.R.).
Chun YangDepartment of Physiology (C.Y., M.T., A.M.G., A.W.C., A.E.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0003-3307-1609 Cary StellohVersiti Blood Research Institute, Milwaukee, WI (A.R., C.S., S.R.).
Monika TutajDepartment of Physiology (C.Y., M.T., A.M.G., A.W.C., A.E.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-0378-4002 Pengyuan LiuDepartment of Physiology, University of Arizona, Tucson (P.L., Y.L., Q.Q., M.L.).
Paul L AuerThe Institute for Health and Equity (P.L.A.), Medical College of Wisconsin, Milwaukee.
Chien-Wei LinDivision of Biostatistics, Data Science Institute (C.-W.L.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0003-4023-7339 Aron M GeurtsDepartment of Physiology (C.Y., M.T., A.M.G., A.W.C., A.E.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-4347-2505 Allen W CowleyDepartment of Physiology (C.Y., M.T., A.M.G., A.W.C., A.E.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-0801-6248 Anne E KwitekDepartment of Physiology (C.Y., M.T., A.M.G., A.W.C., A.E.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0003-1024-4116 Funding
RAT GENOME DATABASER01HL064541 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ANNE E. KWITEK · 1999 to 2026
$50.0MSequencing Coordination and Data Analysis CoreP01HL149620 · NHLBI · UNIVERSITY OF ARIZONA · PI GEURTS, ARON M · 2020 to 2024
$11.8MImpact of L. plantarum 299v Supplementation on Endothelial Function and Systemic InflammationR01HL144098 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2019 to 2022
$2.9MDefining GATA4’s Molecular Function in Gastric Cell BiologyR01DK134064 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BATTLE, MICHELE A, RAO, SRIDHAR · 2022 to 2025
$2.1MHuman Coronary Artery Plaque Transcriptomes and Cardiovascular Risk AssessmentR01HL173778 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MINGYU LIANG, Michael E Widlansky · 2024 to 2026
$2.0MCohesin Mutations in Acute Myelogenous LeukemiaR01CA204231 · NCI · VERSITI WISCONSIN, INC. · PI RAO, SRIDHAR · 2017 to 2021
$1.9MGATA2-TGF beta-TAL1 pathway as a critical mediator of NK Cell developmentR01AI183571 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI BARBARA L. KEE, Subramaniam Malarkannan · 2025 to 2026
$1.5MMedical College of Wisconsin Physician Scientist Immersion ProgramR38HL167238 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MARY EAPEN, Michael E Widlansky · 2023 to 2026
$948kImpact of L. plantarum 299v supplementation on endothelial function and inflammation in humans with type 2 diabetesK24HL152143 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2021 to 2025
$572kNCI NIH HHS R01 CA204231NHLBI NIH HHS K24 HL152143NHLBI NIH HHS P01 HL149620NHLBI NIH HHS R01 HL064541NHLBI NIH HHS R01 HL144098NHLBI NIH HHS R01 HL173778NHLBI NIH HHS R38 HL167238NIAID NIH HHS R01 AI183571NIDDK NIH HHS R01 DK134064
6 · The paper itselfAbstract
backgroundHypertension or elevated blood pressure (BP) is a worldwide clinical challenge and the leading primary risk factor for kidney dysfunctions, heart failure, and cerebrovascular disease. The kidney is a central regulator of BP by maintaining sodium-water balance. Multiple genome-wide association studies revealed that BP is a heritable quantitative trait, modulated by several genetic, epigenetic, and environmental factors. The SNPs identified in genome-wide association studies predominantly (>95%) reside within noncoding genomic regions, making it difficult to understand how they regulate BP. Given the central role of the kidney in regulating BP, we hypothesized that chromatin-accessible regions in renal tissue would be enriched for BP-associated single nucleotide polymorphisms.
methodsWe manually dissected 2 important kidney segments that maintain the sodium-water balance: proximal tubules and medullary thick ascending limbs from the human and rat kidneys. To delineate their chromatin and transcriptomic profiles, we performed the assay for transposase-accessible chromatin and RNA sequencing, respectively.
resultsThe chromatin accessibility maps revealed the shared and unique
conclusionsCollectively, this study lays a foundation for interrogating how intergenic single nucleotide polymorphisms may regulate polygenic traits such as BP.
Indexed as
Blood PressureChromatinHypertensionKidneyKidney Tubules, ProximalPolymorphism, Single NucleotideAnimalsFemaleGenome-Wide Association StudyHumansMaleRatsChromatinblood pressurechromatingenome-wide association studyhypertensionpolymorphism, single nucleotide
Identifiers
PMID39723540
PMCPMC12236357
What Socratic holds
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