Evidence map›Paper›PMID 39723681›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2025

Neuropeptides: The Evergreen Jack-of-All-Trades in Neuronal Circuit Development and Regulation.

Zsofia Hevesi, Tomas Hökfelt, Tibor Harkany

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zsofia HevesiDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Tomas HökfeltDepartment of Neuroscience, Karolinska Institutet, Solna, Sweden.
Tibor HarkanyDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-6637-5900

Funding

Arvid Carlsson FondenAustrian Science Fund FWF-COE16BH2020 European Research Council 2020-AdG-101021016Hjärnfonden FO2022-0300Novo Nordisk Foundation NNF23OC0084476Vetenskapsrådet 2020-01688Vetenskapsrådet 2023-03058
6 · The paper itself

Abstract

Neuropeptides are key modulators of adult neurocircuits, balancing their sensitivity to both excitation and inhibition, and fine-tuning fast neurotransmitter action under physiological conditions. Here, we reason that transient increases in neuropeptide availability and action exist during brain development for synapse maturation, selection, and maintenance. We discuss fundamental concepts of neuropeptide signaling at G protein-coupled receptors (GPCRs), with a particular focus on how signaling at neuropeptide GPCRs could underpin neuronal morphogenesis. We use galanin, a 29/30 amino acid-long neuropeptide, as an example for its retrograde release from the dendrites of thalamic neurons to impact the selection and wiring of sensory afferents originating at the trigeminal nucleus through galanin receptor 1 (GalR

Indexed as

NeuronsNeuropeptidesAnimalsBrainGalaninHumansReceptors, G-Protein-CoupledSignal TransductionSynapsesGalaninNeuropeptidesReceptors, G-Protein-Coupled

Identifiers

PMID39723681
PMCPMC11848124

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.