Evidence map›Paper›PMID 39723808›Full record

ArticleACS chemical neuroscience2025

A Copper-Binding Peptide with Therapeutic Potential against Alzheimer's Disease: From the Blood-Brain Barrier to Metal Competition.

Victor E López-Guerrero, Yanahi Posadas, Carolina Sánchez-López, Amanda Smart, Jael Miranda, Kevin Singewald, Yamir Bandala, Eusebio Juaristi, Christophe Den Auwer, Claudia Perez-Cruz and 4 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Victor E López-GuerreroDepartment of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Yanahi PosadasDepartment of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.ORCID 0000-0003-2480-4233
Carolina Sánchez-LópezCenter for Research in Aging, Center for Research and Advanced Studies (Cinvestav), Mexico City 14330, Mexico.ORCID 0000-0003-4682-2870
Amanda SmartDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, 1156, Santa Cruz 95064, United States.
Jael MirandaDepartment of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Kevin SingewaldDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, 1156, Santa Cruz 95064, United States.
Yamir BandalaDepartment of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Eusebio JuaristiDepartment of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.ORCID 0000-0003-0936-7020
Christophe Den AuwerUniversité Côte d'Azur, CNRS, Institute de Chimie de Nice, Nice 06108, France.ORCID 0000-0003-2880-0280
Claudia Perez-CruzDepartment of Pharmacology, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.ORCID 0000-0002-5983-307X
Lorenza González-MariscalDepartment of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Glenn MillhauserDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, 1156, Santa Cruz 95064, United States.ORCID 0000-0003-2442-7220
Jose SegoviaDepartment of Physiology, Biophysics, and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Liliana QuintanarDepartment of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.ORCID 0000-0003-3090-7175

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI KEITH O HODGSON · 2020 to 2026
$43.3M
IRACDA at UCSC and CSUMBK12GM139185 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI FORSBERG, CAMILLA, HINCK, LINDSAY E · 2020 to 2024
$4.1M
Supplement Request for Emergency Replacement of EPR Amplifier and Acquisition of a Low Volume Resonator for Membrane ProteinsR35GM131781 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI GLENN L MILLHAUSER · 2019 to 2026
$3.6M
UCSC IMSDT32GM135742 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Melissa S Jurica · 2020 to 2026
$2.7M
800 MHz NMR Spectrometer and Helium CryoprobeS10OD018455 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2015 to 2015
$2.0M
Upgrade of a Pulsed Electron Paramagnetic Resonance SpectrometerS10OD024980 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2018 to 2018
$1.5M
NIGMS NIH HHS K12 GM139185NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R35 GM131781NIGMS NIH HHS T32 GM135742NIH HHS S10 OD018455NIH HHS S10 OD024980
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia worldwide. AD brains are characterized by the accumulation of amyloid-β peptides (Aβ) that bind Cu

Indexed as

Alzheimer DiseaseBlood-Brain BarrierChelating AgentsCopperOligopeptidesAmyloid beta-PeptidesAnimalsHumansPeptide FragmentsAmyloid beta-PeptidesChelating AgentsCopperOligopeptidesPeptide FragmentsAlzheimer′s diseasechelation therapycopperNMDA receptorprion protein

Identifiers

PMID39723808
PMCPMC11741003

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.