Evidence map›Paper›PMID 39724468›Full record

ArticleDigestive diseases and sciences2025

Time to Therapy May Not Impact Diagnosis Upstaging in Patients Referred for Management of Luminal Gastrointestinal Neoplasia.

Jennifer M Kolb, Christian Davis, Camille J Hochheimer, Sarah Beilke, Irvin Ma, Charlie Fox, Jazmyne Gallegos, Jack O'Hara, Wyatt Tarter, Sachin Wani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer M KolbVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Christian DavisDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Camille J HochheimerDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA.
Sarah BeilkeDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Irvin MaDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Charlie FoxDivision of Gastroenterology, Hepatology, & Nutrition, University of Utah, Salt Lake City, USA.
Jazmyne GallegosDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Mail Stop F735, 1635 Aurora Court, Rm 2.03, Aurora, CO, 80045, USA.
Jack O'HaraDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Mail Stop F735, 1635 Aurora Court, Rm 2.03, Aurora, CO, 80045, USA.
Wyatt TarterDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA.
Sachin WaniDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Mail Stop F735, 1635 Aurora Court, Rm 2.03, Aurora, CO, 80045, USA. sachin.wani@cuanschutz.edu.

Funding

GASTROINTESTINAL DISEASE TRAINING GRANTT32DK007038 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COLGAN, SEAN P · 1986 to 2020
$3.5M
NIDDK NIH HHS T32 DK007038NIH HHS T32-DK007038
6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic dramatically impacted endoscopy practice. Recommendations were to postpone elective cases, including procedures for removal of luminal neoplasia. This provided a natural experiment to evaluate outcomes related to these decisions and the impact of time to procedure on change in histology.

aimsThe primary aim is to examine time to endoscopy for therapy of colorectal polyps and Barrett's esophagus with dysplasia and oncologic outcomes during the COVID-19 pandemic.

methodsThis was a retrospective cohort study of individuals referred for endoscopic therapy of advanced colorectal polyps and dysplastic Barrett's esophagus (BE) between July 2019 and January 2022. Multivariable logistic regression was used to evaluate whether time to therapeutic exam was associated with a change in histology. Time from index to therapeutic exam before versus after the start of the pandemic (March 20, 2020) was compared using a Cox regression.

resultsThere were 310 patients (56% male, mean age 65) who were referred for colon polyps (n = 256) and BE-related neoplasia (n = 54). The median time to therapeutic exam was 78 days (range 4-718). Time to therapy was shorter for colon polyp cases completed after versus before the pandemic (HR: 1.49, 95% CI 1.14-1.96). The pandemic was not associated with a difference in time to exam for BE. Change in histology from index to therapeutic exam was noted in 51 cases (16.5%) and was mostly upstaging (70.6%). There was no association between time to therapeutic exam, sex, or timing related to the pandemic on the probability of being upstaged for colon polyps or BE.

conclusionsFewer than 1 in 5 cases had a change in histology from index to therapeutic exam, and there was no delay related to the COVID-19 pandemic. These findings suggest that procedures for removal of advanced colon polyps or dysplastic BE can potentially be postponed with minimal impact, helping guide triaging decisions going forward.

Indexed as

Barrett EsophagusColonic PolypsCOVID-19Gastrointestinal NeoplasmsTime-to-TreatmentAgedFemaleHumansMaleMiddle AgedNeoplasm StagingReferral and ConsultationRetrospective StudiesSARS-CoV-2Time FactorsBarrett’s esophagusColon cancerColon polypCOVID-19Pandemic

Identifiers

PMID39724468
PMCPMC11839399

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.