Evidence map›Paper›PMID 39724973›Full record

ArticleThe Journal of allergy and clinical immunology2025

Esophageal epithelial Ikkβ deletion promotes eosinophilic esophagitis in experimental allergy mouse model.

Margarette H Clevenger, Cenfu Wei, Adam L Karami, Lia E Tsikretsis, Dustin A Carlson, John E Pandolfino, Nirmala Gonsalves, Deborah R Winter, Kelly A Whelan, Marie-Pier Tétreault

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In one paragraph

Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The oesophagus as an immune organ.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  2. Mouse models of eosinophilic esophagitis: molecular and translational insights.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Margarette H ClevengerDepartment of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Cenfu WeiDepartment of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Adam L KaramiDepartment of Cancer & Cellular Biology, Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pa.
Lia E TsikretsisDepartment of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Dustin A CarlsonDepartment of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill.
John E PandolfinoDepartment of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Nirmala GonsalvesDepartment of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Deborah R WinterDepartment of Medicine, Rheumatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Kelly A WhelanDepartment of Cancer & Cellular Biology, Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pa.
Marie-Pier TétreaultDepartment of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: marie-pier.tetreault@northwestern.edu.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Role of altered response to volumetric distension in esophageal diseaseP01DK117824 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEEFER, LAURIE A · 2018 to 2022
$7.3M
Investigating the role of mitochondria in Eosinophilic Esophagitis pathogenesis.R01DK121159 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WHELAN, KELLY A · 2019 to 2023
$2.4M
Alternative Mechanisms of Monocyte Transendothelial Migration in InflammationF31HL147413 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CLEVENGER, MARGARETTE HELEN · 2019 to 2024
$211k
The 10x Chromium System for High-Throughput Single Cell GenomicsS10OD025120 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WANG, XINKUN · 2019 to 2019
$79k
NCI NIH HHS P30 CA060553NHLBI NIH HHS F31 HL147413NIDDK NIH HHS P01 DK117824NIDDK NIH HHS R01 DK121159NIH HHS S10 OD025120
6 · The paper itself

Abstract

backgroundEosinophilic esophagitis (EoE) is a chronic T

objectiveWe investigated the role of epithelial IKKβ/NF-κB signaling in EoE pathogenesis using a mouse model with conditional Ikkβ knockout in esophageal epithelial cells (Ikkβ

methodsEoE was induced in Ikkβ

resultsIkkβ

conclusionLoss of epithelial IKKβ signaling exacerbates EoE pathogenesis, highlighting the critical role of this pathway in maintaining epithelial homeostasis and preventing allergic inflammation. The Ikkβ

Indexed as

Eosinophilic EsophagitisEpithelial CellsEsophagusI-kappa B KinaseAnimalsDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutNF-kappa BSignal TransductionI-kappa B KinaseIkbkb protein, mouseNF-kappa Bbasal cell hyperplasiadifferentiationEosinophilic esophagitisepithelial remodelingesophagusIKKβinflammationsingle-cell RNA sequencingT(H)2 response

Identifiers

PMID39724973
PMCPMC11972898

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.