Evidence mapPaperPMID 39725804Full record

ReviewGeroScience2025

Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.

Sabrina Summer, Maria Borrell-Pages, Rosa-Maria Bruno, Rachel E Climie, Konstantina Dipla, Aysenur Dogan, Kseniia Eruslanova, Emil Fraenkel, Francesco Mattace-Raso, Christopher J A Pugh and 12 more

Abstract readReview
In one paragraph

Review in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Emergency trauma admissions in the oldest-old: short- and long-term mortality and the role of frailty in a Turkish national cohort of centenarians.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  3. Nutrition and longevity - diet in centenarians.Journal of translational medicine · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Sabrina SummerDepartment for Biomedical Research, University for Continuing Education Krems, Krems, Austria.ORCID 0000-0002-1489-8638
Maria Borrell-PagesMolecular Pathology and Therapeutic of Ischemic and Atherothrombotic Diseases, Institute de Recerca Sant Pau (IR-Sant Pau), Barcelona Spain. CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-1759-9756
Rosa-Maria BrunoUniversité Paris Cité, INSERM, Paris Cardiovascular Research Center-PARCC, Paris, France.
Rachel E ClimieMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.ORCID 0000-0002-7960-360X
Konstantina DiplaDepartment of Sports Sciences at Serres, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0001-5902-3467
Aysenur DoganDepartment of Medical Biology, School of Medicine, Yeditepe University, Istanbul, Türkiye.ORCID 0000-0002-9572-7979
Kseniia EruslanovaRussian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University, Moscow, Russia.ORCID 0000-0003-0048-268X
Emil FraenkelDepartment of Internal Medicine, University of Košice, Košice, Slovakia.ORCID 0000-0002-3902-5067
Francesco Mattace-RasoDepartment of Internal Medicine, Erasmus University Rotterdam, Rotterdam, Netherlands.ORCID 0000-0002-1688-6497
Christopher J A PughSchool of Sport & Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID 0000-0002-5932-4793
Keith D RochfortSchool of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.ORCID 0000-0003-1198-5952
Mark RossInstitute of Life and Earth Sciences, Heriot-Watt University, Edinburgh, UK.ORCID 0000-0002-0204-3915
Lynn RothLaboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.ORCID 0000-0003-1397-1810
Arno Schmidt-TrucksässDepartment of Sport, Exercise and Health, Division of Sport and Exercise Medicine, University of Basel, Basel, Switzerland.ORCID 0000-0002-4662-3911
Dennis SchwarzDepartment of Cardiology I-Coronary and Peripheral Vascular Disease, University of Münster, Münster, Germany.ORCID 0009-0000-6881-1182
James ShadiowSchool of Kinesiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0293-6753
Yahya SohrabiDepartment of Cardiology I-Coronary and Peripheral Vascular Disease, University of Münster, Münster, Germany.ORCID 0000-0001-5268-238X
Jannik SonnenbergDepartment of Cardiology I-Coronary and Peripheral Vascular Disease, University of Münster, Münster, Germany.ORCID 0000-0001-8262-0980
Olga Tura-CeideInstitut d'Investigació Biomèdica de Girona, Girona, Spain.ORCID 0000-0003-4334-9790
Bilge Guvenc TunaDepartment of Biophysics, School of Medicine, Yeditepe University, Istanbul, Türkiye.ORCID 0000-0003-1348-1336
Josep JulveEndocrinology, Diabetes and Nutrition Group, Institut de Recerca SANT PAU, Barcelona, Spain.ORCID 0000-0002-6531-2246
Soner DoganDepartment of Medical Biology, School of Medicine, Yeditepe University, Istanbul, Türkiye. soner.dogan@yeditepe.edu.tr.ORCID 0000-0002-7762-8109

Funding

European Cooperation in Science and Technology CA18216
6 · The paper itself

Abstract

The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population. Understanding the mechanisms that affect vascular ageing in centenarians and the underlying factors could offer valuable insights for developing strategies to improve overall healthy life span in the elderly. This review discusses these key factors influencing vascular ageing and how their modulation could foster healthy longevity.

Indexed as

AgingCardiovascular DiseasesHealthy AgingLongevityAged, 80 and overGastrointestinal MicrobiomeHumansLife StyleMaleOxidative StressRisk FactorsCardiovascular diseasesCentenariansHealth spanHealthy vascular ageing

Identifiers

PMID39725804
PMCPMC11872877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.