ArticleEuropean journal of medical research2024
Association between body temperature and all-cause mortality in patients with sepsis: analysis of the MIMIC-IV database.
Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Admission body temperature and in-hospital mortality in critically ill children with pneumonia: a retrospective cohort study.BMC pediatrics · 2026Article
- Machine learning-based risk prediction of 28-day mortality for sepsis patients with augmented renal clearance.Scientific reports · 2026Article
- Intermittent Hypothermia in Hodgkin's Lymphoma: A Potential Indicator for Urgent Chemotherapy Initiation.Case reports in medicine · 2026Article
- Body temperature as a dynamic host-response biomarker in sepsis: trajectories and time-varying mortality risk.Frontiers in cellular and infection microbiology · 2026Article
- Temperature profiles in adult intensive care unit patients treated for infection in a tertiary intensive care unit: A single-centre prospective observational cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Sepsis in the absence of fever: Determining the criteria for and feasibility of future therapeutic temperature management trials.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Triage Temperature and Timeliness of Sepsis Interventions in a Pediatric Emergency Department.The western journal of emergency medicine · 2025Article
- Clinical characteristics associated with septic shock complicating hypothermia: a retrospective cohort study from the MIMIC-IV database.European journal of medical research · 2025Article
- Early body temperature trajectories and short term prognosis in sepsis associated acute kidney injury.Scientific reports · 2025Article
- Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit.Open medicine (Warsaw, Poland) · 2025Article
- The V-shaped association between the ratio of neutrophil counts to prognostic nutritional index and 30-, 60-, and 90-day mortality in elderly critically ill patients aged 65 and older with sepsis: a retrospective study based on the MIMIC database.Frontiers in nutrition · 2025Article
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Abstract
backgroundAbnormal body temperature (fever or hypothermia) is a critical symptom in sepsis and is strongly associated with clinical prognosis and disease progression. Given the duality and variability of body temperature fluctuations throughout the disease course, further research is essential to refine clinical strategies for temperature management in sepsis patients.
methodsWe extracted clinical data of sepsis patients from the MIMIC-IV database. A restricted cubic spline (RCS) curve was employed to describe the non-linear relationship between body temperature and clinical outcomes. Based on peak temperature within the first 24 h after admission, patients were categorized into three groups: < 36 °C, 36-38 °C, and > 38 °C. We subsequently matched patients one-to-one into three cohorts using a pairwise propensity score matching (PSM) approach. Alongside clinical data, we conducted log-rank and McNemar tests, and established multiple models, including multiple Cox regression, overlap-weighted (OW) adjusted Cox regression, multiple logistic regression, and OW-adjusted multiple logistic regression, to investigate the impact of temperature on clinical outcomes.
resultsA total of 35,499 sepsis patients were included in my study: 311 with a temperature below 36 °C, 27,538 with a temperature between 36 and 38 °C, and 7650 with a temperature above 38 °C. The RCS analysis revealed a non-linear, U-shaped relationship between body temperature and 28-day, ICU, and in-hospital mortality. Patients with hypothermia had significantly higher 28-day mortality (54.34% vs. 19.28%), ICU mortality (44.37% vs. 12.89%), and in-hospital mortality (49.20% vs. 17.46%) compared to those with hyperthermia. Among patients younger than 65 years, hyperthermia was a protective factor against 28-day mortality relative to normal body temperature, while the opposite was observed in patients aged 65 and older. This trend was consistent in the analysis of ICU and in-hospital mortality.
conclusionsAmong sepsis patients admitted to the ICU, a peak temperature below 36 °C within the first 24 h of admission was associated with higher 28-day mortality. However, no significant difference in clinical prognosis was observed between normothermic and hyperthermic patients.
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