Evidence map›Paper›PMID 39726108›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2025

Identification of Gallbladder-Specific Distal Regulatory Sequence of Murine Sox17.

Shihan Zeng, Ayaka Yanagida, Noriaki Ota, Mami Uemura, Yoshikazu Hirate, Ryuji Hiramatsu, Naoaki Mizuno, Yoshiakira Kanai, Masami Kanai-Azuma

Abstract read
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In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shihan ZengDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.
Ayaka YanagidaDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6350-2185
Noriaki OtaDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.
Mami UemuraDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.
Yoshikazu HirateDepartment of Experimental Animal Model for Human Disease, Institute of Science Tokyo, Tokyo, Japan.
Ryuji HiramatsuDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.
Naoaki MizunoDepartment of Experimental Animal Model for Human Disease, Institute of Science Tokyo, Tokyo, Japan.
Yoshiakira KanaiDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.
Masami Kanai-AzumaDepartment of Experimental Animal Model for Human Disease, Institute of Science Tokyo, Tokyo, Japan.

Funding

Japan Society for the Promotion of Science 18H02361Japan Society for the Promotion of Science 18K14583Japan Society for the Promotion of Science 20H00445Japan Society for the Promotion of Science 21H0238Japan Society for the Promotion of Science 24228005Japan Society for the Promotion of Science 24H00537University of Tokyo
6 · The paper itself

Abstract

Sox17 is a key transcriptional regulator of endoderm formation and function in the gallbladder, blood vessels and reproductive organs. Although multiple transcript variants of Sox17 have been suggested, the precise mechanisms underlying their time- and tissue-specific expression remain unclear. In this study, we discovered two putative regulatory sequences (R1 and R2) adjacent to different transcription start sites of mouse Sox17 exon 1 and generated deletion mice for these regions (Sox17

Indexed as

GallbladderGene Expression Regulation, DevelopmentalSOXF Transcription FactorsAnimalsHMGB ProteinsMiceRegulatory Sequences, Nucleic AcidSOX9 Transcription FactorHMGB ProteinsSox17 protein, mouseSOX9 Transcription FactorSOXF Transcription Factorsgallbladdergene regulationimmunohistochemistry semiquantificationSox17

Identifiers

PMID39726108
PMCPMC11671671

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.