ReviewPain reports2025
Small fiber pathology in fibromyalgia syndrome.
Review in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07682090 (RESET-FMS), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
RESET-FMS: A Randomized Sham-Controlled Trial of Transcutaneous Vagus Nerve Stimulation for Pain, Autonomic Dysfunction, and Fatigue in Patients With Fibromyalgia Syndrome
Who cites it
19 citing papers in PubMed.
- Lesion Without Pain, Pain Without Certainty: A Critical Reappraisal of the NeuPSIG Diagnostic Algorithm for Neuropathic Pain.European journal of pain (London, England) · 2026Review
- Fibromyalgia in men: beyond invisibility-a biopsychosocial and clinical perspective in rheumatology.Clinical rheumatology · 2026Review
- Fibromyalgia: A Multifactorial Pain Disorder.International journal of molecular sciences · 2026Review
- Serum from Fibromyalgia Patients Activates Satellite Glial Cells in Mouse Peripheral Ganglia.Cells · 2026Article
- γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy.Clinical reviews in allergy & immunology · 2026Review
- Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain.The Journal of physiology · 2026Article
- Serum neurofilament light chain in fibromyalgia: comparative evidence of neuronal injury across chronic pain conditions.Pain reports · 2026Article
- Human pain transcriptomics: lessons learned so far.Pain reports · 2026Review
- Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia - overlap, differences, and emerging insights.Journal of translational medicine · 2026Review
- [Fibromyalgia syndrome].Innere Medizin (Heidelberg, Germany) · 2026Review
- Sympathetic skin response in fibromyalgia patients with small fibre pathology.Clinical neurophysiology practice · 2026Article
- Conserved small RNA networks link inflammation to pain signaling in mice and men.Translational psychiatry · 2025Article
- Medical jurisprudence in the context of chronic musculoskeletal nociplastic pain: the clinical medico-legal interface.Pain reports · 2025Review
- Comparative Analysis of Small Nerve Fiber Density in Fibromyalgia Syndrome and Small Fiber Neuropathy.Biomedicines · 2025Article
- Uncovering Hidden Profiles: From Pain-Centric to Multi-Symptom Small Fiber Neuropathy.European journal of neurology · 2025Article
- Pain chronobiology in clinical trial participants with fibromyalgia: a comparison with neuropathic pain.Pain reports · 2025Article
- Neuroinflammatory and Immunological Aspects of Fibromyalgia.Brain sciences · 2025Review
- Investigating Self-Reported Sensory Intolerance and Perceptual Ability Across Sensory Modalities in Fibromyalgia.Journal of pain research · 2025Article
- Improvement of psychological adjustment and pain reduction in fibromyalgia after a qigong training program.Health psychology and behavioral medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About 50% of women with fibromyalgia syndrome have reduced skin innervation. This finding is consistent in patient cohorts from different regions of the world. Small fiber function may also be affected, as shown by various studies using different methods, such as quantitative sensory testing or special small fiber neurophysiology such as C-fiber microneurography. Microneurography in particular has shown increased spontaneous activity, mechanosensitivity, and enhanced activity-induced slowing in C fibers of patients with fibromyalgia. Generalized reduction of skin innervation, ie, proximally and distally, was associated with higher symptom severity and more pronounced central nervous system changes as seen in magnetic resonance tomography. The question whether peripheral or central nervous system changes come first, or whether both are signs of an underlying pathology, has not been resolved yet. For clinical practice, it is important to note that reduced skin innervation in fibromyalgia must not be confused with small fiber neuropathy, which is a separate entity with different characteristics and pathophysiology. Further prospective research is warranted to transfer these findings in the peripheral nervous system into clinical fibromyalgia patient management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.