Evidence mapPaperPMID 39728543Full record

ArticleNanomaterials (Basel, Switzerland)2024

Harshly Oxidized Activated Charcoal Enhances Protein Persulfidation with Implications for Neurodegeneration as Exemplified by Friedreich's Ataxia.

Anh T T Vo, Uffaf Khan, Anton V Liopo, Karthik Mouli, Kenneth R Olson, Emily A McHugh, James M Tour, Madhavan Pooparayil Manoj, Paul J Derry, Thomas A Kent

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anh T T VoCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.ORCID 0000-0001-8400-0291
Uffaf KhanCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
Anton V LiopoCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.ORCID 0000-0003-4218-2159
Karthik MouliCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.ORCID 0000-0002-1671-5727
Kenneth R OlsonDepartment of Physiology, Indiana University School of Medicine South Bend, South Bend, IN 46617, USA.ORCID 0000-0003-0178-2203
Emily A McHughDepartment of Chemistry, Rice University, Houston, TX 77005, USA.
James M TourDepartment of Chemistry, Rice University, Houston, TX 77005, USA.
Madhavan Pooparayil ManojCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
Paul J DerryCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.
Thomas A KentCenter for Genomics and Precision Medicine, Institute of Bioscience and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA.ORCID 0000-0002-9877-7584

Funding

National Institutes of Health - NINDS R01NS094535NINDS NIH HHS R01 NS094535Welch Foundation BE-0048
6 · The paper itself

Abstract

Harsh acid oxidation of activated charcoal transforms an insoluble carbon-rich source into water-soluble, disc structures of graphene decorated with multiple oxygen-containing functionalities. We term these pleiotropic nano-enzymes as "pleozymes". A broad redox potential spans many crucial redox reactions including the oxidation of hydrogen sulfide (H

Indexed as

Keap1nanozymeNrf2oxidized activated carbon nanoparticlespersulfidation

Identifiers

PMID39728543
PMCPMC11728766

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.