ArticleTomography (Ann Arbor, Mich.)2024
Neural Modulation Alteration to Positive and Negative Emotions in Depressed Patients: Insights from fMRI Using Positive/Negative Emotion Atlas.
Article in Tomography (Ann Arbor, Mich.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- The impact of preoperative depressive symptoms on acute and chronic postoperative pain trajectories after orthopedic surgery for adolescent idiopathic scoliosis: a prospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Soft skills and potential covariates in first year health science students in Latin America: a cross-sectional study.Frontiers in psychology · 2026Article
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11 authors.
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Abstract
backgroundAlthough it has been noticed that depressed patients show differences in processing emotions, the precise neural modulation mechanisms of positive and negative emotions remain elusive. FMRI is a cutting-edge medical imaging technology renowned for its high spatial resolution and dynamic temporal information, making it particularly suitable for the neural dynamics of depression research.
methodsTo address this gap, our study firstly leveraged fMRI to delineate activated regions associated with positive and negative emotions in healthy individuals, resulting in the creation of the positive emotion atlas (PEA) and the negative emotion atlas (NEA). Subsequently, we examined neuroimaging changes in depression patients using these atlases and evaluated their diagnostic performance based on machine learning.
resultsOur findings demonstrate that the classification accuracy of depressed patients based on PEA and NEA exceeded 0.70, a notable improvement compared to the whole-brain atlases. Furthermore, ALFF analysis unveiled significant differences between depressed patients and healthy controls in eight functional clusters during the NEA, focusing on the left cuneus, cingulate gyrus, and superior parietal lobule. In contrast, the PEA revealed more pronounced differences across fifteen clusters, involving the right fusiform gyrus, parahippocampal gyrus, and inferior parietal lobule.
conclusionsThese findings emphasize the complex interplay between emotion modulation and depression, showcasing significant alterations in both PEA and NEA among depression patients. This research enhances our understanding of emotion modulation in depression, with implications for diagnosis and treatment evaluation.
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