Evidence map›Paper›PMID 39728938›Full record

ArticleVeterinary sciences2024

First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure.

Debora Groppetti, Giulia Pizzi, Elisa Giussani, Alessandro Pecile, Silvia Michela Mazzola, Valerio Bronzo, Eleonora Fusi

Abstract read
In one paragraph

Article in Veterinary sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Impact of Oxidative Stress and Antioxidants on Semen Quality in Dogs.Animals : an open access journal from MDPI · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Debora GroppettiDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, Italy.ORCID 0000-0003-0566-1580
Giulia PizziPrivate Practitioner, Specialist in Animal Reproduction, 20841 Carate Brianza, MB, Italy.ORCID 0000-0003-2703-0085
Elisa GiussaniDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, Italy.ORCID 0009-0007-9754-5216
Alessandro PecileDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, Italy.ORCID 0000-0001-7326-7046
Silvia Michela MazzolaDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, Italy.ORCID 0000-0001-8131-4340
Valerio BronzoDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, Italy.ORCID 0000-0003-4250-0823
Eleonora FusiDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, Italy.ORCID 0000-0002-5529-6748

Funding

University of Milan Linea2_2019_Groppetti
6 · The paper itself

Abstract

Tobacco smoke has numerous adverse effects on both human and animal health, including impaired reproductive function. Recent research has explored environmental exposure in dogs, investigating various biological matrices. However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aimed to evaluate the detectability of cotinine in the semen of dogs living with smoking owners. Additionally, seminal cotinine concentrations were correlated with those in serum and hair. To further examine the potential impact of smoking on canine fertility, the relationships between seminal cotinine, total sperm concentration, and antioxidant activity in plasma and semen were analyzed in exposed and non-exposed dogs. This study is the first to demonstrate the presence of cotinine in canine ejaculate and its correlation with blood and hair concentrations. While the potential toxic effect of cotinine on seminal parameters and male fertility in dogs requires further investigation, it is crucial to raise awareness among pet owners about the risks associated with domestic smoking for their animals.

Indexed as

cigarettedogoxidative stresssmokingsperm concentration

Identifiers

PMID39728938
PMCPMC11680424

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.