Evidence map›Paper›PMID 39729420›Full record

ReviewCornea2025

Advances in the Diagnosis and Management of Limbal Stem Cell Deficiency.

Thanachaporn Kittipibul, Chea Piseth Dalin, Ali Masoudi, Jie Zheng, Sophie X Deng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cornea, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thanachaporn KittipibulDepartment of Ophthalmology, Center of Excellence for Cornea and Stem Cell Transplantation, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.ORCID 0000-0001-5814-2413
Chea Piseth DalinOphthalmology Unit, Calmette Hospital, Phnom Penh, Kingdom of Cambodia.
Ali MasoudiDepartment of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA.
Jie ZhengDepartment of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA.
Sophie X DengDepartment of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA.ORCID 0000-0002-0499-3877

Funding

Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
Development of small-molecule Wnt mimetics for corneal epithelial cell regenerationR01EY028557 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DENG, SOPHIE, ZHENG, JIE J. · 2018 to 2021
$2.0M
California Institute for Regenerative Medicine TR2-01768, CLIN1-08686, and CLIN2-11650NEI NIH HHS R01 EY021797NEI NIH HHS R01 EY021797, R01 EY028557NEI NIH HHS R01 EY028557
6 · The paper itself

Abstract

abstractThis concise review focuses on the latest advancements in the diagnosis and management of limbal stem cell deficiency (LSCD). Ensuring the standard of care for individuals affected by LSCD involves the crucial task for physicians to meticulously and accurately diagnose the condition and determine its specific stage. A standardized diagnostic approach forms the foundation for formulating and delivering customized therapeutic interventions to maximize treatment outcomes for each patient. In this review, we introduce a systematic diagnostic algorithm to guide the assessment of LSCD. In addition, the current management algorithm and emerging therapies for LSCD are summarized.

Indexed as

Corneal DiseasesDisease ManagementEpithelium, CornealLimbus CorneaeStem CellsStem Cell TransplantationHumansLimbal Stem Cell Deficiency

Identifiers

PMID39729420
PMCPMC11875906

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.