Evidence map›Paper›PMID 39730375›Full record

ArticleScientific reports2024

Global proteomics reveals pathways of mesenchymal stem cells altered by Mycobacterium tuberculosis.

Simran Kaur, Nupur Angrish, Madavan Vasudevan, Garima Khare

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simran Kaur *Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
Nupur Angrish *Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.
Madavan VasudevanGenomics and Data Science Unit, Theomics International Pvt. Ltd, Bangalore, 560038, India.
Garima KhareDepartment of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India. garimakhare@south.du.ac.in.

Funding

Council of Scientific and Industrial Research, India 09/045 (1440)2016 EMR-ICouncil of Scientific and Industrial Research, India 09/045 (1604) 2018 EMR-IDepartment of Science and Technology, Ministry of Science and Technology, India CRG/2018/003325University of Delhi-Institution of Eminence IoE-DU/MRP/2022/056
6 · The paper itself

Abstract

Mycobacterium tuberculosis (M. tb) has a remarkable ability to persist inside host cells. Several studies showed that M. tb infects and survives inside bone marrow mesenchymal stem cells (BM-MSCs) escaping the host immune system. Here, we have identified various cellular pathways that are modulated in human BM-MSCs upon infection with virulent M. tb and the proteomic profile of these cells varies from that of avirulent M. tb infected cells. We found that virulent M. tb infection reshapes host pathways such as stem cell differentiation, alternative splicing, cytokine production, mitochondrial function etc., which might be modulated by M. tb to persist inside this unconventional niche of human BM-MSCs. Additionally, we observed that virulent M. tb infection suppresses various cellular processes. This study uncovers the differences in the host proteomic profiles resulting from the virulent versus avirulent M. tb infection that can pave the way to identify host-directed therapeutic targets for the treatment of tuberculosis.

Indexed as

Mesenchymal Stem CellsMycobacterium tuberculosisProteomicsCell DifferentiationCells, CulturedHost-Pathogen InteractionsHumansProteomeTuberculosisProteomeHost-directed therapeuticsMesenchymal stem cellsMycobacterium tuberculosisPathway analysisProteomics

Identifiers

PMID39730375
PMCPMC11680934

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.