Evidence mapPaperPMID 39730510Full record

ArticleScientific reports2024

Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality.

Orison O Woolcott, Edgar Samarasundera, Alicia K Heath

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

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16citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  16. Relative Fat Mass and Psoriasis Risk: Evidence from NHANES 2009-2014.Journal of multidisciplinary healthcare · 2025
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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Orison O WoolcottSchool of Public Health, Faculty of Medicine, Imperial College London, London, UK. orison.woolcott@imperial.ac.uk.
Edgar SamarasunderaSchool of Public Health, Faculty of Medicine, Imperial College London, London, UK.
Alicia K HeathSchool of Public Health, Faculty of Medicine, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although studies have examined the association of the Relative Fat Mass (RFM, a novel anthropometric index used as a surrogate for whole-body fat percentage) with all-cause mortality, the association of RFM with diabetes-related mortality and heart disease mortality has not been thoroughly investigated. In addition, no study has compared the associations of RFM and waist circumference (a surrogate for intra-abdominal fat) with cause-specific mortality and all-cause mortality. In the present study, we addressed these knowledge gaps. We used data from the US National Health and Nutrition Examination Survey (NHANES) 1999-2018. NHANES III was used for validation. Analyses included 46,535 adults (mean age 46.5 years). During a median follow-up time of 9.7 years, 6,101 participants died (743 from diabetes; 1,514 from heart disease). Compared with BMI and WC, RFM was more strongly associated with diabetes-related mortality in both women and men, adjusting for age, ethnicity, education, and smoking status. All anthropometric measures were similarly strongly associated with heart disease mortality and all-cause mortality. RFM showed greater predictive discrimination of mortality. Similar results were found in NHANES III (n = 14,448). In conclusion, RFM is strongly associated with diabetes-related mortality, heart disease mortality, and all-cause mortality, and outperforms conventional adiposity measures for prediction of mortality.

Indexed as

Diabetes MellitusHeart DiseasesNutrition SurveysAdipose TissueAdiposityAdultBody Mass IndexFemaleHumansMaleMiddle AgedRisk FactorsUnited StatesWaist CircumferenceAbdominal obesityDiabetes mortalityGeneral obesityHeart disease mortalityRelative fat mass

Identifiers

PMID39730510
PMCPMC11681238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.