Evidence map›Paper›PMID 39730743›Full record

ArticleScientific reports2024

Utility of lymphocyte-to-monocyte ratio and pretreatment tooth extraction in intra-arterial chemoradiotherapy for oral cancer to prevent osteoradionecrosis of the jaw.

Kosei Kubota, Ken Furudate, Ryohei Ito, Norihiko Narita, Yusuke Tanaka, Yoshihiro Tamura, Koki Takagi, Shunya Yamazaki, Akihiro Matsumura, Tomoh Matsumiya and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kosei KubotaDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan. kkubota@hirosaki-u.ac.jp.
Ken FurudateDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Ryohei ItoDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Norihiko NaritaDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Yusuke TanakaDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Yoshihiro TamuraDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Koki TakagiDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Shunya YamazakiDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Akihiro MatsumuraDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
Tomoh MatsumiyaDepartment of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori, 036-8564, Japan.
Wataru KobayashiDepartment of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.

Funding

Japan Society for the Promotion of Science 20K10088
6 · The paper itself

Abstract

The objective of this study was to evaluate the utility of inflammation-based prognostic scores (IBPS) in predicting ORN among patients undergoing superselective intra-arterial chemoradiotherapy (SSIACRT). This retrospective cohort study examined the medical records of 54 patients with advanced oral cancer (stage 3 or 4) treated with SSIACRT. The predictor variable was IBPS. The main outcome variable was onset of ORN. Covariates comprised sex, median age, tooth status, tumor size, and pretreatment tooth extraction with professional oral care (pretreatment tooth extraction). For each factor, cumulative incidence and univariate and multivariate analyses of ORN incidence were performed. The cumulative incidence of ORN in patients with pre-treatment lymphocyte-to-monocyte ratio (LMR < 4.95vs LMR ≥4.95, P = 0.01) and pretreatment tooth extraction (no vs. yes, P = 0.03) was significantly different. Univariate and multivariate analyses identified pre-treatment LMR cutoff values < 4.95 and pre-treatment tooth extraction as significantly associated with the development of ORN. Pretreatment tooth extraction reduced the incidence of ORN in low LMR group (P = 0.04). LMR is a useful biomarker to predict ORN in SSIACRT. Pretreatment tooth extraction was a useful treatment to prevent ORN. Pretreatment extraction with LMR may be important for the prevention of ORN in SSIACRT.

Indexed as

ChemoradiotherapyLymphocytesMonocytesMouth NeoplasmsOsteoradionecrosisTooth ExtractionAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesInflammation-based prognostic scoreLymphocyte-to-monocyte ratioOsteoradionecrosis of the jawPretreatment tooth extractionProfessional oral careSuperselective intra-arterial chemoradiotherapy for oral cancer

Identifiers

PMID39730743
PMCPMC11681047

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.