Evidence map›Paper›PMID 39730986›Full record

ArticleInternal and emergency medicine2025

Cardiac vagal control and inflammation are upregulated in exceptional human longevity.

Gabriel Dias Rodrigues, Domenico Azzolino, Valentina Manzini, Marco Proietti, Angelica Carandina, Costanza Scatà, Chiara Bellocchi, Eleonora Tobaldini, Evelyn Ferri, Beatrice Arosio and 2 more

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In one paragraph

Article in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gabriel Dias RodriguesDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.ORCID 0000-0002-9258-2954
Domenico AzzolinoGeriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122, Milan, Italy.
Valentina ManziniDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Marco ProiettiDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Angelica CarandinaDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Costanza ScatàDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Chiara BellocchiDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Eleonora TobaldiniDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Evelyn FerriGeriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122, Milan, Italy.
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Matteo CesariDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy.
Nicola MontanoDepartment of Clinical Sciences and Community Health, University of Milan, via Francesco Sforza 35, 20122, Milan, Italy. nicola.montano@unimi.it.

Funding

Velux Stiftung a marker of agingVelux Stiftung clinical characterization of fatigueVelux Stiftung Development of novel research strategies for the biologicalVelux Stiftung paradigm of complexityVelux Stiftung potential target of interventions
6 · The paper itself

Abstract

We investigated the interplay of cardiovascular autonomic and inflammatory profiles in persons with extreme longevity (PEL), their direct offsprings (DO), and a group of controls matched for age and sex with the DO. Cardiac autonomic control was assessed through the heart rate variability (HRV) using spectral and symbolic analysis. The plasma concentration and gene expression of interleukin (IL)-10, IL-6, and TNF-α were quantified. In PEL, the sympatho-vagal is shifted to a vagal predominance and both pro- and anti-inflammatory circulation cytokines are increased compared to DO and controls. Also, no differences were found in HRV between DO and controls. These preliminary results suggest that environmental factors, at least in our small sample, may overcome the impact of heritability on cardiac autonomic control and inflammatory circulation cytokines.

Indexed as

InflammationLongevityVagus NerveAgedAged, 80 and overAutonomic Nervous SystemCytokinesFemaleHeart RateHumansInterleukin-6MaleMiddle AgedTumor Necrosis Factor-alphaUp-RegulationCytokinesInterleukin-6Tumor Necrosis Factor-alphaAutonomic nervous systemHeart rate variabilityInflammagingLongevityLow-grade inflammation

Identifiers

PMID39730986

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.