Evidence map›Paper›PMID 39731500›Full record

ArticleVirulence2025

Arginine depletion-induced autophagy and metabolic dysregulation are involved in the disease severity of hand, foot, and mouth disease.

Yuefei Jin, Wangquan Ji, Liang Zhang, Dejian Dang, Bingqing Yu, Xiaolong Zhang, Yuxiang Zhang, Jiaqi Li, Yaodong Zhang, Rongxin Yang and 4 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuefei JinDepartment of Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Wangquan JiDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.ORCID 0000-0002-4489-1592
Liang ZhangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Dejian DangDepartment of Infection Control, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Bingqing YuDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Xiaolong ZhangNHC Key Laboratory of Birth Defects Prevention, Henan Key Laboratory of Population Defects Prevention, Zhengzhou, China.
Yuxiang ZhangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Jiaqi LiDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Yaodong ZhangHenan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Rongxin YangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Haiyan YangDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Shuaiyin ChenDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Fang WangDepartment of Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Guangcai DuanDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.ORCID 0009-0002-4963-2060

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amino acid metabolism provides significant insight into the development and prevention of many viral diseases. Therefore, the present study aimed to compare the amino acid profiles of hand, foot, and mouth disease (HFMD) patients with those of healthy individuals and to further reveal the molecular mechanisms of HFMD severity. Using UPLC-MS/MS, we determined the plasma amino acid expression profiles of pediatric patients with HFMD (mild,

Indexed as

ArginineAutophagyHand, Foot and Mouth DiseaseAmino AcidsAnimalsBrainChildChild, PreschoolDisease Models, AnimalEnterovirus A, HumanFemaleHumansInfantMaleMetabolomicsMiceAmino AcidsArginineTOR Serine-Threonine KinasesarginineautophagyCVA6Hand, foot, and mouth diseasemTOR

Identifiers

PMID39731500
PMCPMC12915399

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.