Evidence map›Paper›PMID 39732640›Full record

ArticleBMC infectious diseases2024

Comparison of clinical characteristics and outcomes in candidaemia patients with and without COVID-19: a multicentre retrospective study.

Sung Un Shin, Sohyun Bae, David Cho, Ahrang Lee, Hae Seong Jeong, Soyoon Hwang, Sarah Kim, Minji Kim, Seong Eun Kim, Uh Jin Kim and 4 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Clinical characteristics and co-infection analysis of influenza a virus in pediatric respiratory infections: a study based on tNGS technology.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sung Un ShinDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Sohyun BaeDivision of Infectious Disease, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, 130, Dongdeok‑ro, Jung‑gu, Daegu, 41944, South Korea.
David ChoDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Ahrang LeeDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Hae Seong JeongDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Soyoon HwangDivision of Infectious Disease, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, 130, Dongdeok‑ro, Jung‑gu, Daegu, 41944, South Korea.
Sarah KimDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Minji KimDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Seong Eun KimDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Uh Jin KimDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Seung-Ji KangDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Kyung-Hwa ParkDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea.
Hyun-Ha ChangDivision of Infectious Disease, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, 130, Dongdeok‑ro, Jung‑gu, Daegu, 41944, South Korea. changhha@knu.ac.kr.
Sook In JungDepartment of Infectious Disease, Department of Internal Medicine, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, South Korea. sijung@chonnam.ac.kr.

Funding

Korea Health Industry Development Institute HE20C0017050021
6 · The paper itself

Abstract

backgroundInvasive fungal infections have been reported as complications with significant mortality and morbidity in patients hospitalized with COVID-19. This study aimed to evaluate the clinical characteristics and outcomes of candidaemia patients with COVID-19 and to investigate the association between COVID-19 and mortality in candidaemia patients.

methodsThis retrospective study included candidaemia patients aged 18 years or older admitted to four university-affiliated tertiary hospitals in South Korea between January 1, 2020, and December 31, 2022. The COVID-19 group comprised patients diagnosed with COVID-19 before the onset of candidaemia. Clinical features and outcomes were compared between the COVID-19 and non-COVID-19 groups. Multivariate logistic regression analyses were performed to identify risk factors related to 30-day mortality.

resultsOf the 355 patients diagnosed with candidaemia, 39 (11.0%) had a prior diagnosis of COVID-19. The COVID-19 group exhibited greater rates of systemic corticosteroid use (20.5% vs. 8.9%, p = 0.042), central venous catheter use (74.4% vs. 57.3%, p = 0.041), and mechanical ventilation (53.8% vs. 31.6%, p = 0.006) before the onset of candidaemia. The COVID-19 group had a greater rate of septic shock at the onset of candidaemia (61.5% vs. 32.0%, p < 0.0001) and a greater 30-day mortality rate (69.2% vs. 50.9%, p = 0.031). K‒M survival analysis revealed that patients in the COVID-19 group had a lower 30-day survival rate than did those without COVID-19 (p = 0.003 by log-rank test). However, in multivariate logistic regression analysis, COVID-19 did not significantly impact 30-day mortality.

conclusionsAccording to multivariate logistic regression analysis, COVID-19 was not an independent risk factor for mortality. However, candidaemia patients with a prior COVID-19 diagnosis were more likely to exhibit critical conditions such as mechanical ventilation and experience poor outcomes. Therefore, clinicians need to monitor and prevent candidaemia in critically ill patients with COVID-19.

Indexed as

CandidemiaCOVID-19SARS-CoV-2AdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRepublic of KoreaRespiration, ArtificialRetrospective StudiesRisk FactorsCandidaemiaCOVID-19Mechanical ventilationMortality

Identifiers

PMID39732640
PMCPMC11682618

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.