ArticleBMC pulmonary medicine2024
Association between geriatric nutritional risk index and adverse outcomes in critical ill patients with chronic obstructive pulmonary disease: a cohort study of 2824 older adults.
Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Frequency of Exacerbations in Patients with COPD and Their Nutritional Status: A Multicenter Study.Medicina (Kaunas, Lithuania) · 2026Article
- Geriatric nutritional risk index and mortality risk in elderly patients with rheumatoid arthritis: evidence from NHANES (1999-2018).Clinical rheumatology · 2026Article
- The geriatric nutritional risk index as a prognostic risk factor for critically ill patients with atrial fibrillation: a retrospective study based on MIMIC-IV and local hospital cohort external validation.Frontiers in nutrition · 2026Article
- Comparison of Tools for Nutrition Assessment in Stable Subjects with Chronic Obstructive Pulmonary Disease: Which is the Best Mortality Predictor in Real Clinical Practice?International journal of chronic obstructive pulmonary disease · 2026Observational
- A machine learning-based prediction model for delirium risk in malnourished elderly ICU patients with SHAP interpretability.Frontiers in nutrition · 2026Article
- Diagnostic value of geriatric nutritional risk index and phase angle for malnutrition in patients with COPD: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Inflammation and Albumin-Based Biomarkers Are Not Independently Associated with Mortality in Critically Ill COPD Patients: A Retrospective Study.Life (Basel, Switzerland) · 2025Article
- Factors Influencing Pressure Injury Development and Survival Duration in Adults Admitted to the ICU: A Retrospective Cohort Study Following the STROBE Guidelines.Healthcare (Basel, Switzerland) · 2025Article
- Association between the geriatric nutritional risk index and adverse post-extubation outcomes for critically ill older adults: a retrospective study.BMC pulmonary medicine · 2025Article
- Predictive Value of Geriatric Nutritional Risk Index for Readmission within 6-Months in Elderly Inpatients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Dietary antioxidants and nutritional risk in the elderly: insights from the composite dietary antioxidant index and geriatric nutritional risk index.Frontiers in immunology · 2025Article
- Association between nutritional risk and CRP levels in patients with acute exacerbation of chronic obstructive pulmonary disease.Frontiers in medicine · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
objectivesChronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, particularly among the elderly, resulting in high rates of intensive care unit (ICU) admissions. Malnutrition is common in elderly patients and has been associated with poor prognosis in patients with COPD. However, its impact in the ICU setting remains incompletely defined. The objective of this study is to examine the association between malnutrition, as measured by the Geriatric Nutritional Risk Index (GNRI), and adverse outcomes in older patients with COPD in the ICU.
methodsA cohort study of 2,824 older COPD patients admitted to the ICU from 2008 to 2019 was conducted. The association between GNRI scores and outcomes including in-hospital mortality, risk of pressure injuries, and length of ICU stay was evaluated. Odds ratios (OR) and 95% confidence intervals (CI) were calculated. A causal mediation analysis was employed to identify potential mediating variables and to calculate the proportion mediated.
resultsThe median age of study participants was approximately 75 years, with 1,281 (45.4%) being female. Lower GNRI scores (GNRI ≤ 98) were significantly associated with increased in-hospital mortality (OR: 1.48, 95% CI: 1.08-2.05, p = 0.015), higher incidence of pressure injuries (OR: 1.97, 95% CI: 1.54-2.54, p < 0.001), and longer ICU stays (OR: 1.51, 95% CI: 1.18-1.94, p = 0.001). Mediation analysis indicated that pressure injury accounted for approximately 22.9% of the association between malnutrition and in-hospital mortality.
conclusionsLower GNRI scores, indicative of malnutrition, are associated with adverse outcomes in elderly ICU patients with COPD. The findings highlight the importance of early nutritional assessment and intervention in this high-risk group to improve survival and reduce complications.
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